| Hyperintense nodules on non-enhanced T1-weighted gradient-echo magnetic resonance imaging of cirrhotic liver: fate and clinical implications. | |
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MedLine Citation:
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PMID: 16888794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the fate of hyperintense hepatic nodules on nonenhanced T1-weighted (T1w) gradient-echo (GRE) magnetic resonance (MR) images in cirrhotic patients. MATERIALS AND METHODS: A total of 79 cirrhotic patients with hyperintense nodules (>5 mm) on precontrast opposed-phase (repetition time (TR)/echo time (TE) = 140/2.7 msec) GRE images from initial MRI without T2-weighted (T2w) hyperintensity or arterial hypervascularity were subjected to analysis of subsequent MR images obtained at intervals of 12-56 months (mean = 24.5 months). Multiplicity of hyperintense nodules (group A, up to 8; group B, >8) was correlated with follow-up changes. RESULTS: Group B patients were younger (P = 0.003) than group A patients (mean = 47.5 and 56.2 years, respectively). In 66 group A patients, 39 out of 143 lesions (27%) were enlarged, including 20 malignantly transformed or borderline lesions. Of the 104 lesions (the eight largest lesions in each patient) in 13 group B patients, only three (2.9%) were enlarged. The results of best- and worst-case analyses showed that overall the lesions were benign in 91% and 82% of patients, respectively. CONCLUSION: T1w hyperintense nodules without T2w hyperintensity or arterial hypervascularity in the cirrhotic liver are benign in most cases. In younger patients with numerous macronodules, almost all of these lesions follow a benign course. |
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Authors:
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Jeong-Sik Yu; Jei Hee Lee; Mi-Suk Park; Ki Whang Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 24 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2007-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 630-6 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, YongDong Severance Hospital, Gangnam-Gu, Seoul, Republic of Korea. yjsrad97@yumc.yonsei.ac.kr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cell Transformation, Neoplastic Contrast Media / pharmacology Female Fibrosis / diagnosis*, pathology* Humans Liver / pathology* Liver Neoplasms / pathology Magnetic Resonance Imaging / methods* Male Middle Aged Retrospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
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