| Hyperintense lesions in brain MRI after exposure to a mercuric chloride-containing skin whitening cream. | |
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MedLine Citation:
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PMID: 21052738 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Exposure to inorganic mercury (Hg) is a serious problem presenting with a combination of neurological and psychiatric symptoms along with weight loss, pruritus, erythema, arterial hypertension, tachycardia, and renal tubular dysfunction. We report a 4-year-old girl with chronic intoxication of inorganic mercury secondary to the accidental use of an Hg(2)Cl(2)- and HgCl(2)-containing skin whitening cream (urine level of Hg, 41.1 μg/l; reference level, <25 μg/l). Under treatment with dimercapto-1-propansulficacid, Hg level in the urine raised to 1,175.5 μg/l, neurological deterioration occurred, and brain magnetic resonance imaging (MRI) showed on fluid attenuated inversion recovery sequences new hyperintense lesions in the subcortical white matter. After 4 months, clinical signs and symptoms and brain MRI findings resolved. This is a first case of inorganic mercury poisoning showing hyperintense lesions in brain MRI and confirms earlier cases showing transient deterioration during chelation therapy. Although urinary excretion could be enhanced during chelation therapy, signs and symptoms of intoxication could be worsened. |
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Authors:
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Marcus R Benz; Seung-Hee Lee; Lars Kellner; Christoph Döhlemann; Steffen Berweck |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: European journal of pediatrics Volume: 170 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 747-50 Citation Subset: IM |
Affiliation:
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Dr. von Haunersches Kinderspital, University Children's Hospital, Ludwigs-Maximilians-University, Munich, Lindwurmstrasse 4, 80337, Munich, Germany, Marcus.Benz@med.uni-muenchen.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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