| Hyperinsulinemic euglycemia therapy for stunned myocardium following subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 18821837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors describe the clinical course of a 50-year-old woman who presented with life-threatening cardiac dysfunction after aneurysmal subarachnoid hemorrhage (Fisher Grade 4). The pathophysiology of cardiac injury in this setting is not fully understood, but excess sympathetic activation can lead to neurogenic stressed myocardium. A metabolic intervention using the continuous intravenous infusion of high doses of insulin with euglycemia resulted in a rapid improvement of cardiac contractility. The observed benefit could be due to better myocardial glucose utilization that could not have been achieved by catecholamine administration. |
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Authors:
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Abel Vanderschuren; Philippe Hantson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 110 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-05 Completed Date: 2009-02-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 64-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Intensive Care Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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metabolism* Cardiac Output Electrocardiography Humans Hypoglycemic Agents / administration & dosage, therapeutic use* Infusions, Intravenous Insulin / administration & dosage, therapeutic use* Intensive Care Long QT Syndrome / drug therapy, etiology Male Middle Aged Myocardial Stunning / drug therapy*, etiology* Subarachnoid Hemorrhage / complications* Tachycardia, Sinus / drug therapy, etiology Troponin I / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Troponin I; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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