Document Detail

Hyperinsulinemia increases the risk of gestational hypertension.
MedLine Citation:
PMID:  8960995     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether hyperinsulinemia is related to gestational hypertension. METHODS: We measured the arterial blood pressure and the level of immunoreactive insulin (IRI) during a 75 g oral glucose tolerance test in a total of 84 pregnant women. Hyperinsulinemia was defined as a fasting IRI level > or = 9 IU/l, while gestational hypertension was defined as arterial blood pressure > or = 140/90 mmHg. RESULTS: The incidence of gestational hypertension was higher in the hyperinsulinemic group (n = 29) than in the control group (n = 55) (24.1% vs. 7.3%, respectively P < 0.05). After controlling for maternal age, parity, pre-pregnancy body mass index and the gestational age at the time of oral glucose tolerance test (OGTT), using a multiple regression model, the relative risk of developing gestational hypertension for a fasting insulin level was 1.19 (95% C.I., 1.03-1.38). CONCLUSION: Pregnant women with hyperinsulinemia are at increased risk of developing gestational hypertension.
T Hamasaki; I Yasuhi; M Hirai; H Masuzaki; T Ishimaru
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  55     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-12     Completed Date:  1997-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, Japan.
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MeSH Terms
Glucose Tolerance Test
Hyperinsulinism / complications*
Hypertension / complications*
Multivariate Analysis
Pregnancy Complications*
Pregnancy Complications, Cardiovascular*
Pregnancy Trimester, Second
Prospective Studies

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