| Hyperinsulinaemia in ischaemic heart disease: the importance of myocardial infarction and left ventricular function. | |
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MedLine Citation:
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PMID: 8153289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated circulating insulin levels have been reported in ischaemic heart disease, and may be of aetiological importance. Previous studies have not considered the potential influence of heart failure or of previous myocardial infarction, as opposed to stable angina. We therefore measured the insulin response to a 75 g oral glucose tolerance test in five groups with normal glucose tolerance, comparing normal male controls to men with chronic stable angina, men with recent myocardial infarction (two groups, 3 weeks and 3 months post infarction), and men with chronic severe heart failure. Only patients with chronic heart failure had fasting hyperinsulinaemia, probably reflecting associated neuroendocrine abnormalities. Stimulated hyperinsulinaemia was present in all patient groups, but was less pronounced and of shorter duration in patients with angina. At 120 min, only patients with heart failure or previous myocardial infarction were hyperinsulinaemic. The degree of stimulated hyperinsulinaemia was not influenced by the presence of heart failure or by the length of time from infarction. Hyperinsulinaemia is associated with impaired peripheral muscle glucose uptake and metabolism, and might contribute to muscular fatigue on exertion in patients with previous myocardial infarction or heart failure. |
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Authors:
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R A Wright; A D Flapan; F Stenhouse; C Simpson; L Flint; N A Boon; K G Alberti; R A Reimersma; K A Fox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Quarterly journal of medicine Volume: 87 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-05-12 Completed Date: 1994-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 131-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Unit, University of Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Angina Pectoris / metabolism Blood Glucose / analysis Cardiac Output, Low / metabolism Glucose / administration & dosage Glucose Tolerance Test Humans Hyperinsulinism / complications*, metabolism, physiopathology Male Middle Aged Myocardial Infarction / metabolism Myocardial Ischemia / complications*, metabolism, physiopathology Random Allocation Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-99-7/Glucose |
| Comments/Corrections | |
Comment In:
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Q J Med. 1994 May;87(5):317
[PMID:
7695698
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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