Document Detail


Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial.
MedLine Citation:
PMID:  8652974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The therapeutic efficacy of hyperimmune bovine colostrum (HBC) from cows immunized with four serotypes of human rotavirus was evaluated in a double-blind, randomized trial in 75 boys, aged 6-24 months, infected with rotavirus diarrhoea. The treatment group received 100 ml of HBC three times a day for 3 consecutive days, while the controls received the same amount of bovine colostrum from significantly shorter duration of diarrhoea than the controls (median 56 versus 72 h (p<0.001); confidence interval of median difference (CI) 8-32 h). Total stool output (g/kg) between admission and cessation of diarrhoea was reduced by 29% in the HBC-treated group compared with controls (median 205 versus 290 g (p=0.04); CI = 1-154 g). In 50% of the children in the study group, diarrhoea stopped by 48 h, whereas 100% of the controls were still suffering from diarrhoea. No untoward effects were noted in either group. Colostrum from cows immunized with rotavirus antigen is clinically effective in reducing the duration and severity of childhood diarrhoea due to rotavirus.
Authors:
A K Mitra; D Mahalanabis; H Ashraf; L Unicomb; R Eeckels; S Tzipori
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  84     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-07-31     Completed Date:  1996-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  996-1001     Citation Subset:  IM    
Affiliation:
International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka Bangladesh.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Child, Preschool
Colostrum / immunology*
Diarrhea, Infantile / immunology,  therapy*,  virology
Double-Blind Method
Humans
Infant
Male
Rotavirus Infections / immunology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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