| Hyperhomocysteinemia and venous thrombosis. | |
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MedLine Citation:
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PMID: 17433898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been recognized, since the first description of the disease, that arterial and venous thrombosis are common in patients with homocysteinuria. Interest in the condition increased with reports from a large number of mainly retrospective studies showing that mildly elevated homocysteine levels are also associated with venous thromboembolism (VTE), thrombotic stroke, and peripheral vascular disease. This association is less strong when populations are studied prospectively. Vitamin supplementation, primarily with folic acid, and to a lesser degree with pyridoxine and vitamin B(12), is effective in reducing elevated levels of plasma homocysteine. Surprisingly, however, recent prospective intervention studies showed that despite lowering of the homocysteine level with such treatment, there was no impact on the risk of recurrence of venous or arterial disease. |
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Authors:
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Alex Gatt; Michael Makris |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in hematology Volume: 44 ISSN: 0037-1963 ISO Abbreviation: Semin. Hematol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-16 Completed Date: 2007-05-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404514 Medline TA: Semin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 70-6 Citation Subset: IM |
Affiliation:
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Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Homocysteine / blood, metabolism* Humans Hyperhomocysteinemia / physiopathology* Methylenetetrahydrofolate Reductase (NADPH2) / genetics, metabolism Pregnancy Pregnancy Complications, Hematologic / metabolism Prospective Studies Retrospective Studies Venous Thrombosis / blood*, physiopathology |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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