Document Detail

Hyperhomocysteinemia and venous thrombosis.
MedLine Citation:
PMID:  17433898     Owner:  NLM     Status:  MEDLINE    
It has been recognized, since the first description of the disease, that arterial and venous thrombosis are common in patients with homocysteinuria. Interest in the condition increased with reports from a large number of mainly retrospective studies showing that mildly elevated homocysteine levels are also associated with venous thromboembolism (VTE), thrombotic stroke, and peripheral vascular disease. This association is less strong when populations are studied prospectively. Vitamin supplementation, primarily with folic acid, and to a lesser degree with pyridoxine and vitamin B(12), is effective in reducing elevated levels of plasma homocysteine. Surprisingly, however, recent prospective intervention studies showed that despite lowering of the homocysteine level with such treatment, there was no impact on the risk of recurrence of venous or arterial disease.
Alex Gatt; Michael Makris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in hematology     Volume:  44     ISSN:  0037-1963     ISO Abbreviation:  Semin. Hematol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-16     Completed Date:  2007-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404514     Medline TA:  Semin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK.
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MeSH Terms
Homocysteine / blood,  metabolism*
Hyperhomocysteinemia / physiopathology*
Methylenetetrahydrofolate Reductase (NADPH2) / genetics,  metabolism
Pregnancy Complications, Hematologic / metabolism
Prospective Studies
Retrospective Studies
Venous Thrombosis / blood*,  physiopathology
Reg. No./Substance:
454-28-4/Homocysteine; EC Reductase (NADPH2)

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