Document Detail

Hyperhomocysteinemia and the presence of cardiovascular disease are associated with kynurenic acid levels and carotid atherosclerosis in patients undergoing continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  21906785     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Hyperhomocysteinemia and the activation of kynurenine (KYN) pathway have been reported as the factors participated in atherosclerosis in uraemic patients. The objective of this study was to verify whether hyperhomocysteinemia may be involved in atherosclerotic cardiovascular disease (CVD) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). MATERIALS AND METHODS: We determined the plasma concentrations of KYN, KYNA, KYNA/KYN ratio, homocysteine (Hcy) and intima-media thickness (IMT) - an early reflection of the systemic atherosclerosis in CAPD patients both with and without CVD and healthy controls. RESULTS: KYNA concentrations and KYNA/KYN ratio were about 3 times higher in the patients with hyperhomocysteinemia (Hcy>15μM) compared to those with normal Hcy levels (<15μM), and they were significantly lower in CVD[+] than in CVD[-] patients in these studied groups. The presence of CVD was associated with higher Hcy levels only in the patients with Hcy>15μM. The positive association was between Hcy and KYNA, KYNA/KYN ratio in all CAPD patients and in CVD[+] patients with hyperhomocysteinemia. IMT was positively associated with Hcy levels in patients with hyperhomocysteinemia, whereas there was no relationship between IMT and KYNA concentrations in the studied groups. CONCLUSIONS: These results showed the association between hyperhomocysteinemia and carotid atherosclerosis as well as the possible role of hyperhomocysteinemia in the activation of KYNA production in CAPD patients. The elevated KYNA levels observed in patients with hyperhomocysteinemia seem to be protective against Hcy-mediated atherosclerosis in these patients.
Krystyna Pawlak; Michal Mysliwiec; Dariusz Pawlak
Related Documents :
22214735 - Classic and non-classic forms of mitral valve prolapse.
22261695 - Electrocardiographic findings in sickle cell cardiovascular autonomic neuropathy.
21948975 - High levels of serum uric acid impair development of coronary collaterals in patients w...
21813065 - Soluble macrophage-derived cd163 is a marker of disease activity and progression in ear...
3809995 - Oesophagus scintigraphy in patients with diabetes mellitus.
3888135 - 'drug holidays' in the treatment of parkinson's disease. a brief review.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-8
Journal Detail:
Title:  Thrombosis research     Volume:  -     ISSN:  1879-2472     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A biomonitoring framework to support exposure and risk assessments.
Next Document:  Does the Pulmonary Embolism Severity Index accurately identify low risk patients eligible for outpat...