Document Detail

Hyperhomocysteinemia and pregnancy--review of our present understanding and therapeutic implications.
MedLine Citation:
PMID:  11074137     Owner:  NLM     Status:  MEDLINE    
Homocysteine results from the transmethylation of methionine. Its metabolism depends primarily on three enzymes and several vitamin cofactors. Genetic abnormality in these enzymes or deficiency of these vitamins lead to hyperhomocysteinemia (HHCh). HHCh is usually biologically defined by a fasting value >15 micromol/l. HHCh belongs among the congenital hypercoagulable states and is a long-known vascular disease risk factor. The discovery that HHCh may also be responsible for several pregnancy complications has only recently been made. Studies in this area are still scarce and report on limited numbers of patients. It nevertheless appears clear that HHCh is associated with the syndromes of repeated miscarriage, pre-eclampsia, placenta abruptio, thromboembolic events, neural tube defects, and perhaps with fetal death-in-utero and intra-uterine growth retardation. Supplementation with vitamin B9 can reduce plasma HC levels, and is thus recommended in patients with HHCh. The prevention of thromboembolic events during pregnancy by anticoagulant treatment is also desirable in these patients.
Y Aubard; N Darodes; M Cantaloube
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  93     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Division of Obstetrics and Gynecology, CHU Dupuytren 2 av. Martin-Luther-King 87042 Limoges, Cedex, France.
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MeSH Terms
Abortion, Habitual / etiology
Anticoagulants / therapeutic use
Fetal Death / etiology
Fetal Growth Retardation / etiology
Homocysteine / blood*
Neural Tube Defects / etiology
Pre-Eclampsia / etiology
Pregnancy Complications / blood,  therapy*
Venous Thrombosis / etiology
Reg. No./Substance:
0/Anticoagulants; 454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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