Document Detail


Hyperhomocysteinemia in preeclampsia is associated to higher risk pressure profiles.
MedLine Citation:
PMID:  14650644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homocysteine levels have been determined with Chromatography on HPLC column, between the 20th and the 24th week of pregnancy, in women with analogous characteristics (a) normotensive, (b) with pregnancy-induced hypertension (PIH), low (LR), medium (MR), high risk (HR). The group they belonged to was confirmed after natural or caesarean delivery. All the patients were submitted to 24 hour blood pressure monitoring for the evaluation of further pressure risk parameters: mean arterial pressure (MAP), non dippers, percentages of pressure peaks. Homocysteine levels in normotensive pregnant women (5.8 +/- 1.7 microM) were low. Significant high levels of homocysteine were present proportionally to the risk degree of PIH. Higher levels of homocysteine statistically significant were present in non dippers of all groups (MR p < 0.05; HR p < 0.01). A direct correlation between plasmatic homocisteine levels and pressure profiles was found out in non dippers (r = 0.56, r = 0.55, r = 0.50 respectively) and in dippers (r = 0.7, r = 0.75, r = 0.60 respectively), and also between levels of homocysteine, MAP value, and pathological percentages of systolic and diastolic nocturnal peaks. In pregnant women presenting preeclampsia afterwards, high levels of homocysteine were not different from mean values present in high risk PIH pregnant women (13.3 +/- 1.9 vs. 16.4 +/- 1.7 microM). High levels of homocysteine early determined in the second trimester of PIH pregnancies seem to be associated to a pregnancy higher risk, coexisting with dangerous pressure profiles. High levels confirm a pregnant woman to belong to a higher or lower risk degree of vascular damage, but in the same group context high levels of homocisteine do not allow to identify those pregnant women who will develop eclampsia.
Authors:
R Noto; S Neri; Z Noto; D Cilio; G Abate; P Noto; F Pepi; A Leanza; G Molino
Related Documents :
15785004 - Trends in prevalence, awareness, treatment and control of hypertension in the middle-ag...
7728284 - Red blood cell sodium and potassium concentration and blood pressure. the gubbio popula...
6500684 - Fifteen-year survival of patients beginning treatment with methyldopa between 1962 and ...
6872284 - The value of the mean arterial blood pressure in the second trimester (map-2 value) as ...
15596574 - Microangiopathic hemolysis and renal failure in malignant hypertension.
7768294 - Acth-(1-24) blocks the decompensatory phase of the haemodynamic response to acute hypov...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  7     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-12-02     Completed Date:  2004-01-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  81-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Systemic Diseases, University of Catania, School of Medicine, Catania, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Homocysteine / blood*
Humans
Hyperhomocysteinemia / blood,  complications*
Pre-Eclampsia / blood,  complications*,  diagnosis*
Pregnancy
Pregnancy Complications, Cardiovascular / blood
Time Factors
Chemical
Reg. No./Substance:
454-28-4/Homocysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurotensin pulmonary metabolism in normal and asthmatic subjects.
Next Document:  Use of mental health and substance abuse services among high-cost Medicaid enrollees.