Document Detail


Hyperhomocysteinemia in dementia.
MedLine Citation:
PMID:  11458999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.
Authors:
F Leblhuber; J Walli; E Artner-Dworzak; K Vrecko; B Widner; G Reibnegger; D Fuchs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  107     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2000  
Date Detail:
Created Date:  2001-07-18     Completed Date:  2001-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1469-74     Citation Subset:  IM    
Affiliation:
Department of Gerontology, Landesnervenklinik Wagner Jauregg, Linz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*,  complications,  psychology
Cognition Disorders / blood
Dementia, Vascular / blood*,  complications,  psychology
Female
Folic Acid / blood
Homocysteine / blood*
Humans
Hyperhomocysteinemia / blood*,  complications
Male
Mental Status Schedule
Pilot Projects
Reference Values
Regression Analysis
Risk Factors
Vitamin B 12 / blood
Chemical
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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