Document Detail

Hyperhomocysteinemia in L-dopa treated patients with Parkinson's disease: potential implications in cognitive dysfunction and dementia?
MedLine Citation:
PMID:  20666719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperhomocysteinemia has been associated with cognitive dysfunction and dementia. The incidence of dementia in Parkinson's Disease (PD) patients is higher than in the general population and plasma Homocysteine concentrations are increased in L-dopa treated PD patients.
OBJECTIVE: We evaluated the possible correlations between L-Dopa related hyperhomocysteinemia and cognitive dysfunction in PD.
METHODS: A Medline literature search was performed to identify all published studies on Homocysteine and cognitive dysfunction and dementia during the course of PD from 1966 to 31/03/2010.
RESULTS: Sixteen studies were found for review; ten studies focused on homocysteine and cognitive dysfunction in PD patients, five on homocysteine and PD dementia and two on homocysteine and markers of neurodegeneration in PD. The design of the study was retrospective in 14 studies, while 2 had a prospective design, with a variable follow-up period (from 24-weeks to 2 years). In most of the studies plasma homocysteine levels significantly correlated with cognitive functions, dementia and markers of neurodegeneration in PD patients. However, some studies did not confirm these findings. Several factors may concur to explain these partially conflicting results, including the retrospective design of the studies, their small sample size, their high percentage of excluded patients, and the use of a wide range of neuropsychological tasks in assessment of cognitive dysfunctions across the available studies.
CONCLUSIONS: Available data seem to indicate a potential role of L-dopa related hyperhomocysteinemia on cognitive impairment and dementia during the course of PD.
S Zoccolella; S V Lamberti; G Iliceto; A Santamato; P Lamberti; G Logroscino
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  17     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3253-61     Citation Subset:  IM    
Clinic of Nervous System Diseases, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Department of Medical and Neurological Sciences, University of Foggia, Foggia, Italy.
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MeSH Terms
Antiparkinson Agents / adverse effects*,  therapeutic use
Cognition Disorders / etiology*
Dementia / etiology*
Homocysteine / metabolism
Hyperhomocysteinemia / etiology*
Levodopa / adverse effects*,  therapeutic use
Neurons / metabolism
Parkinson Disease / complications*,  drug therapy,  pathology
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 454-28-4/Homocysteine

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