| Hyperhomocysteinemia in Alzheimer Dementia Patients and Cognitive Decline after 6 Months Follow-up Period. | |
| | |
MedLine Citation:
|
PMID: 20824536 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract- Objective: White matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are commonly found in Alzheimer's disease (AD) and may contribute to cognitive impairment. Plasma total homocysteine (tHcy) had also been linked with cognitive decline in AD. We examined the relationship among change of cognition, tHcy level, and WMHs on MRI in AD patients with a follow-up periods of 6 months. Methods: AD patients with normal creatinine level and initial clinical dementia rating (CDR) of 1 to 2 were enrolled. tHcy and biochemistry tests related to cerebral vascular risk factors were collected. WMHs were measured on MRI fluid attenuated inverse recovery sequence and classified into deep white matter hyperintensities (DWMHs) and periventricular white matter hyperintensities (PWMHs) by visual rating scale. Neuropsychological tests including cognitive ability screening instrument (CASI), mini-mental state examination (MMSE) converted from CASI scores and CDR were collected twice during the follow- up period of 6 months. Results: Ninety-two AD patients, 30 men and 62 women completed the study while the tHcy level was not significantly different between AD and age matched controls. tHcy level showed no correlation with CASI or MMSE score, at either the first or second examination. tHcy showed positive correlation with decline of CASI total score and abstract thinking (both p less 0.01) but not in MMSE decline. There was no significant correlation between neuropsychiatric assessment and WMHs, but the decline of abstract thinking score was related to frontal PWMHs (R square = 0.237, p = 0.007). Conclusion: tHcy might be associated with rapid cognitive decline in AD after a 6-month follow-up period and the effect might not be directly through WMHs. tHcy level correlated with greater WMHs in the trigone area although greater lesion load by MRI was in the occipital lobe. |
| | |
Authors:
|
Min-Chien Tu; Chi-Wei Huang; Nai-Ching Chen; Wen-Neng Chang; Chun-Chung Lui; Chih-Feng Chen; Ching Chen; Ya-Ling Wang; Yu-Ting Lin; Chiung-Chih Chang |
Related Documents
:
|
19607926 - Multi-parametric classification of alzheimer's disease and mild cognitive impairment: t... 18477326 - Determination of cadesi-03 thresholds for increasing severity levels of canine atopic d... 8496126 - Magnetic resonance imaging in patients with concurrent tourette's disorder and asperger... 16513606 - Dual-tracer dopamine transporter and perfusion spect in differential diagnosis of parki... 10209796 - Strain on intervertebral discs after anterior cervical decompression and fusion. 3140636 - Mr and ct characteristics of gangliocytoma: a rare cause of epilepsy in children. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta neurologica Taiwanica Volume: 19 ISSN: 1028-768X ISO Abbreviation: Acta Neurol Taiwan Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815355 Medline TA: Acta Neurol Taiwan Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 164-73 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center and Chang Gung University College of Medicine, Kaohsiung,Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Homocysteine, cognition and brain white matter hyperintensities.
Next Document: Supratentorial deep-seated bacterial brain abscess in adults: clinical characteristics and therapeut...