| Hyperhomocysteinemia decreases bone blood flow. | |
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MedLine Citation:
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PMID: 21339911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated plasma levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), are associated with osteoporosis. A decrease in bone blood flow is a potential cause of compromised bone mechanical properties. Therefore, we hypothesized that HHcy decreases bone blood flow and biomechanical properties. To test this hypothesis, male Sprague-Dawley rats were treated with Hcy (0.67 g/L) in drinking water for 8 weeks. Age-matched rats served as controls. At the end of the treatment period, the rats were anesthetized. Blood samples were collected from experimental or control rats. Biochemical turnover markers (body weight, Hcy, vitamin B(12), and folate) were measured. Systolic blood pressure was measured from the right carotid artery. Tibia blood flow was measured by laser Doppler flow probe. The results indicated that Hcy levels were significantly higher in the Hcy-treated group than in control rats, whereas vitamin B(12) levels were lower in the Hcy-treated group compared with control rats. There was no significant difference in folate concentration and blood pressure in Hcy-treated versus control rats. The tibial blood flow index of the control group was significantly higher (0.78 ± 0.09 flow unit) compared with the Hcy-treated group (0.51 ± 0.09). The tibial mass was 1.1 ± 0.1 g in the control group and 0.9 ± 0.1 in the Hcy-treated group. The tibia bone density was unchanged in Hcy-treated rats. These results suggest that Hcy causes a reduction in bone blood flow, which contributes to compromised bone biomechanical properties. |
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Authors:
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Neetu Tyagi; Thomas P Vacek; John T Fleming; Jonathan C Vacek; Suresh C Tyagi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-25 |
Journal Detail:
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Title: Vascular health and risk management Volume: 7 ISSN: 1178-2048 ISO Abbreviation: Vasc Health Risk Manag Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-06-13 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101273479 Medline TA: Vasc Health Risk Manag Country: New Zealand |
Other Details:
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Languages: eng Pagination: 31-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY, USA. n0tyag01@louisville.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Biomechanics Blood Pressure Bone Density Bone Remodeling Disease Models, Animal Folic Acid / blood Homocysteine / blood* Hyperhomocysteinemia / blood, complications*, physiopathology Laser-Doppler Flowmetry Male Osteoporosis / blood, etiology*, physiopathology Rats Rats, Sprague-Dawley Regional Blood Flow Tibia / blood supply*, physiopathology Time Factors Up-Regulation Vitamin B 12 / blood |
| Grant Support | |
ID/Acronym/Agency:
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HL-71010/HL/NHLBI NIH HHS; NS-51568/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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