| Hyperhomocysteinemia and alternate vitamin supplementation | |
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MedLine Citation:
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PMID: 17342693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Treatment with folic acid and vitamin B 12 appears to be effective in lowering total plasma Homocysteine (tHcy) concentration, but whether vitamin B 12 alone decreases tHcy in patients with normal vitamin B 12 status is still unknown. The aims of the present study were to explore the effect of alternate vitamin supplementation with folic acid or vitamin B 12 on tHcy concentrations in haemodialysis (HD) patients, and to compare changes in tHcy concentrations with MTHFR genotype. METHODS: 74 patients, 44 men and 30 women, were recruited and randomized blindly into two groups of 37 subjects each. The first group was initially treated with vitamin B 12 for two months, and with folic acid for the following two months; the second group was supplemented in the reverse order. In both groups the treatment was followed by a 2-month washout period. tHcy levels were measured at the beginning of treatment (T0), after two months (T1), four months (T2), and at the end of the washout period (T3). Vitamin B 12 and folate were taken at T0 and T3. RESULTS: The genotype frequency was: C/C 37%, C/T 34%, T/T 29%. tHcy decreased in both groups following the alternate vitamins therapy. This decrease was greater for the T/T genotype (p<0.05) and was more significant when the treatment start-ed with folic acid (p<0.01). Moreover, after the washout period, tHcy increased remarkably without significant differences between diffusive and convective techniques. Folate levels at the end of study appeared to be reduced in haemodialysis patients. Vitamin B 12 concentration significantly increased in patients on diffusive haemodialysis, confirming the fundamental role of membrane performance. CONCLUSION: The alternate vitamin treatment demonstrated the importance of folate therapy and the secondary contribution of vitamin B 12 in lowering tHcy in HD patients. |
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Authors:
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S De Angelis; A Noce; M Dess?; A Pastore; F Scaccia; M Trombetta; C Tozzo; G Splendiani |
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Publication Detail:
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Type: English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Giornale italiano di nefrologia : organo ufficiale della Societ? italiana di nefrologia Volume: 24 ISSN: 0393-5590 ISO Abbreviation: G Ital Nefrol Publication Date: 2007 Jan-Feb |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426434 Medline TA: G Ital Nefrol Country: Italy |
Other Details:
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Languages: ita Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Policlinico Universitario Tor Vergata, Roma - Italy. annalisa.noce@fastwebnet.it |
Vernacular Title:
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Iperomocisteinemia nei pazienti uremici: effetti della supplementazione alternata di acido folico e vitamina B 12. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Dietary Supplements Female Folic Acid / therapeutic use* Humans Hyperhomocysteinemia / drug therapy* Male Middle Aged Vitamin B 12 / therapeutic use* Vitamin B Complex / therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
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12001-76-2/Vitamin B Complex; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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