Document Detail


Hyperhomocysteinemia and the MTHFR C677T mutation in central retinal vein occlusion.
MedLine Citation:
PMID:  10893069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hyperhomocysteinemia is a factor that predisposes to thrombosis, and the C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) is known to give increased plasma homocysteine. We wanted to investigate if these factors were overrepresented in a group of patients with central retinal vein occlusion. METHODS: 116 patients with a history of central retinal vein occlusion were examined for the presence of hyperhomocysteinemia and the MTHFR C677T mutation. RESULTS: Compared to the control groups, there was no significant increase, neither in plasma homocysteine nor in the frequency of the MTHFR C677T mutation in the patients. Even when we looked selectively at the young patients, age less than 50 years, no difference could be detected. CONCLUSION: It seems that neither hyperhomocysteinemia nor the MTHFR C677T mutation is an important risk factor for the aetiology of central retinal vein occlusion.
Authors:
J Larsson; B Hultberg; A Hillarp
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  78     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-11-07     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Lund University Hospital, Sweden. Jorgen.Larsson@oft.lu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
DNA / analysis*
Electrophoresis, Polyacrylamide Gel
Female
Gene Frequency
Genetic Markers
Genotype
Humans
Hyperhomocysteinemia / enzymology,  genetics*
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Oxidoreductases Acting on CH-NH Group Donors / blood,  genetics*
Point Mutation*
Retinal Vein Occlusion / enzymology,  etiology,  genetics*
Risk Factors
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-49-2/DNA; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

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