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Hyperhemolysis Syndrome Complicating Pregnancy in Homozygous δβ-Thalassemia.
MedLine Citation:
PMID:  22239462     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hyperhemolysis syndrome in patients with sickle cell disease who are given compatible blood has been well described in the literature but a similar condition complicating pregnancy in β-thalassemia (β-thal) has not been reported. Pregnancy itself or continuation of blood transfusions can further exacerbate the condition which may become life-threatening. The exact mechanism of hyperhemolysis is not well understood. A bystander hemolysis mechanism has been proposed. Treatment with steroids, immunoglobulins and cyclosporin can be life saving.
Authors:
Joseph Mechery; Kehinde Abidogun; Fiona Crosfill; James Jip
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Hemoglobin     Volume:  -     ISSN:  1532-432X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynaecology, Royal Preston Hospital , Preston, Lancashire , UK.
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