| Hyperhomocysteinemia and cardiovascular risks in hemodialysis patients. | |
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MedLine Citation:
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PMID: 20814121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of premature and progressive occlusive vascular disease is high in chronic uremic patients, and it accounts for more than 40% of the mortality in dialysis patients. End stage renal failure (ESRF) patients exhibit elevated plasma homocystein levels, about four fold as much as those in the controls, and it is now considered as a causative factor for increased risk of cardiovascular death among these patients. The aim of this study was to evaluate the relationship of total plasma homocysteine level and echocardiographic abnormalities as a surrogate of cardiac disease outcome in hemodialysis patients. 123 adult patients on maintenance hemodialysis and having echocardiography done during January till November 2006 were enrolled in this cross-sectional study. Plasma homocysteine level was directly related to the presence of aortic regurgitation r= 0.27 P= 0.009. There were negative correlations between ejection fraction (EF), left ventricular systolic dimension (LV.S) (r= - 0.71, P= 0.0001), left ventricular diastolic dimension (LV.D) (r= -0.23 p= 0.01) and age (r= - 0.021 P= 0.02). In conclusion we did not find the paradoxical reverse epidemiology in our patients and plasma total homocysteine level was in direct correlation with cardiac risk factors such as left ventricular mass index and aortic regurgitation. |
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Authors:
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Mohammad Mahdi Sagheb; Mohammad Ali Ostovan; Zahra Sohrabi; Elham Atabati; Ghanbar Ali Raisjalai; Jamshid Roozbeh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Volume: 21 ISSN: 1319-2442 ISO Abbreviation: Saudi J Kidney Dis Transpl Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9436968 Medline TA: Saudi J Kidney Dis Transpl Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 863-6 Citation Subset: IM |
Affiliation:
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Shiraz University of Medical Sciences, Shiraz, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Valve Insufficiency / etiology Biological Markers / blood Cardiovascular Diseases / etiology*, physiopathology, ultrasonography Cross-Sectional Studies Echocardiography, Doppler Echocardiography, Doppler, Color Female Homocysteine / blood* Humans Hyperhomocysteinemia / blood, complications* Iran Kidney Failure, Chronic / complications, therapy* Male Middle Aged Myocardial Contraction Renal Dialysis / adverse effects* Risk Assessment Risk Factors Stroke Volume Up-Regulation Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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