Document Detail

Hypergonadotropic hypogonadism in oligophrenia.
MedLine Citation:
PMID:  685719     Owner:  NLM     Status:  MEDLINE    
Eight patients representing five different, probably hereditary neurological syndromes with oligophrenia and hypogonadism as the common features have been examined clinically and endocrinologically. Two sisters suffered from polyneuropathy, one male from ataxia, one male from spastic tetraplegia, two sisters and a brother from myopathy and one male patient from epilepsy and polyneuropathy. The latter patient was diagnosed as having an acute intermittent porphyria. All the patients had degenerative neurological disorders. The karyotypes were normal. The patients all had signs of hypogonadism. Four male patients had marked testicular atrophy but otherwise normal external genitalia. The testosterone levels in the blood were normal or slightly decreased. Three of the females had their menarche at a normal age but a very early menopause. The fourth female has never menstruated. The four females had normal breasts and body hair. All patients had high basal luteinizing hormone (LH) and follicle-stimulating hormone levels and the response to i.v. LH-releasing hormone was exaggerated. The prolactin values were normal. None of the examined patients had any signs of thyroid or adrenal insufficiency and the sella turcica was normal. A possible etiology to their hypergonadotropic hypogonadism is discussed.
P O Lundberg; A C Nilsson; L Wide
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  204     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1978  
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  AIM; IM    
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MeSH Terms
Ataxia / complications,  genetics
Epilepsy / complications,  genetics
Estradiol / blood
Follicle Stimulating Hormone / blood
Gonadotropins, Pituitary / blood*
Hypogonadism / etiology*,  genetics
Luteinizing Hormone / blood
Mental Retardation / complications*,  genetics
Middle Aged
Muscular Diseases / complications,  genetics
Polyneuropathies / complications,  genetics
Prolactin / blood
Quadriplegia / complications,  genetics
Testosterone / blood
Reg. No./Substance:
0/Gonadotropins, Pituitary; 50-28-2/Estradiol; 58-22-0/Testosterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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