Document Detail


Hyperglycosylated hCG: a variant with separate biological functions to regular hCG.
MedLine Citation:
PMID:  17081684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperglycosylated hCG (hCG-H) is an over-glycosylated variant of hCG. While regular hCG is produced by differentiated syncytotrophoblast cells, hCG-H is independently secreted by stem cytotrophoblast cells. hCG-H has an independent function to regular hCG. It is the direct promoter of trophoblast invasion and malignancy. Invasion as in implantation of pregnancy and malignancy as in choriocarcinoma. Neither will occur in the absence of hCG-H. hCG-H measurements have multiple functions. Primarily or exclusively hCG-H is produced at the time of implantation of pregnancy and in the 2 weeks that follows. As such, a good pregnancy test should measure regular hCG and hCG-H equally. This is not commonly the case. Most tests poorly detect hCG-H. New pregnancy tests are needed, including those that measure only hCG-H. Considering that hCG-H is critical for implantation, hCG-H is also invaluable for determining pregnancy outcome and detecting failures. It makes a considerable more accurate test for detecting pregnancy failures and ectopic pregnancies than regular hCG. Down syndrome pregnancies are marked by poor trophoblast differentiation. As such, they are very well marked by using a combination of hCG-H measurements and other screening tests. hCG-H is also an absolute tumor marker for malignant or invasive gestational trophoblastic disease, it can discriminate active and inactive (quiescent) disease, and the need for chemotherapy.
Authors:
Laurence A Cole; Sarah A Khanlian
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-11-01
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  260-262     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  228-36     Citation Subset:  IM    
Affiliation:
USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM 87104, United States. larry@hcglab.com
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / analysis,  chemistry,  metabolism*
Down Syndrome / diagnosis
Female
Glycosylation
Humans
Pregnancy
Pregnancy Outcome
Pregnancy Tests
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/glycosylated HCG

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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