| Hyperglycemia-related pathophysiologic mechanisms and potential beneficial actions of melatonin. | |
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MedLine Citation:
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PMID: 18855729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronically-elevated blood glucose initiates a harmful series of processes in which toxic reactive species play crucial roles. Oxidative as well as nitro-oxidative stress is harmful for virtually all biomolecules including lipids, proteins and DNA. Such pathophysiologic mechanisms eventually results in cellular dysfunction, apoptosis or necrosis. Melatonin is a multifunctional indolamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity. These are related to melatonin's antioxidative, anti-inflammatory and possibly epigenetic regulatory properties. Current knowledge encourages using this non-toxic indolamine either as a sole treatment or in conjunction with other treatments for inhibition of the biohazards of hyperglycemia. |
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Authors:
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Ahmet Korkmaz; Turgut Topal; Sukru Oter; Dun-Xian Tan; Russel J Reiter |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 8 ISSN: 1389-5575 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2008-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1144-53 Citation Subset: IM |
Affiliation:
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Gulhane Askeri Tip Akademisi, Fizyoloji Anabilim Dali, 06018 Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Hyperglycemia / metabolism*, physiopathology* Melatonin / metabolism* Oxidative Stress Poly(ADP-ribose) Polymerases / metabolism Reactive Nitrogen Species / metabolism Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Reactive Nitrogen Species; 0/Reactive Oxygen Species; 73-31-4/Melatonin; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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