Document Detail

Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly.
MedLine Citation:
PMID:  17329914     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of subclinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly. METHODS: The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A(1c) (HbA(1c)) levels were used as an index of glycemic control. RESULTS: The HbA(1c) level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The HbA(1c) was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01+/-0.29%, 5.57+/-0.09% and 5.42+/-0.05%, respectively). Furthermore, the HbA(1c) adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA(1c) level was significantly and independently associated with the CRP level. CONCLUSIONS: These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.
Masayo Fukuhara; Kiyoshi Matsumura; Masanori Wakisaka; Yutaka Takata; Kazuo Sonoki; Kiyoshi Fujisawa; Toshihiro Ansai; Sumio Akifusa; Koji Fujii; Mitsuo Iida; Tadamichi Takehara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-01     Completed Date:  2007-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Division of General Internal Medicine, Kyushu Dental College, Kitakyushu, Japan.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Blood Pressure*
C-Reactive Protein / analysis*
Hemoglobin A, Glycosylated / analysis*
Hyperglycemia / blood,  complications*,  physiopathology*
Regression Analysis
Vasculitis / blood,  diagnosis*,  etiology*
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobin A, Glycosylated; 9007-41-4/C-Reactive Protein

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