| Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. | |
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MedLine Citation:
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PMID: 11753019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Volatile anesthetics stimulate but hyperglycemia attenuates activity of mitochondrial adenosine triphosphate-regulated potassium channels. The authors tested the hypothesis that acute hyperglycemia interferes with isoflurane-induced preconditioning in vivo. METHODS: Barbiturate-anesthetized dogs (n = 79) were instrumented for measurement of hemodynamics. Myocardial infarct size and collateral blood flow were assessed with triphenyltetrazolium chloride staining and radioactive microspheres, respectively. All dogs were subjected to a 60-min left anterior descending coronary artery occlusion followed by 3 h of reperfusion. Dogs were randomly assigned to receive an infusion of normal saline (normoglycemic controls) or 15% dextrose in water to increase blood glucose concentrations to 300 or 600 mg/dl in the absence or presence of isoflurane (0.5 or 1.0 minimum alveolar concentration [MAC]) in separate experimental groups. Isoflurane was discontinued, and blood glucose concentrations were allowed to return to baseline values before left anterior descending coronary artery occlusion. RESULTS: Myocardial infarct size was 26 +/- 1% of the left ventricular area at risk in control experiments. Isoflurane reduced infarct size (15 +/- 2 and 13 +/- 1% during 0.5 and 1.0 MAC, respectively). Hyperglycemia alone did not alter infarct size (26 +/- 2 and 33 +/- 4% during 300 and 600 mg/dl, respectively). Moderate hyperglycemia blocked the protective effects of 0.5 MAC (25 +/- 2%) but not 1.0 MAC isoflurane (13 +/- 2%). In contrast, severe hyperglycemia prevented reductions of infarct size during both 0.5 MAC (29 +/- 3%) and 1.0 MAC isoflurane (28 +/- 4%). CONCLUSIONS: Acute hyperglycemia attenuates reductions in myocardial infarct size produced by isoflurane in dogs. |
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Authors:
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Franz Kehl; John G Krolikowski; Boris Mraovic; Paul S Pagel; David C Warltier; Judy R Kersten |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 96 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2001-12-25 Completed Date: 2002-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, 53226, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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pharmacology* Animals Dogs Female Hemodynamics / drug effects Ischemic Preconditioning* Isoflurane / pharmacology* Male Myocardial Infarction / prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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AA 12331/AA/NIAAA NIH HHS; GM 08377/GM/NIGMS NIH HHS; HL 03690/HL/NHLBI NIH HHS; HL 54280/HL/NHLBI NIH HHS; HL 63705/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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