| Hyperglycemia and mortality in elderly patients with Staphylococcus aureus bacteremia. | |
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MedLine Citation:
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PMID: 17396726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the association between hyperglycemia and in-hospital mortality in elderly patients with Staphylococcus aureus bacteremia (SAB). METHODS: We reviewed the medical records of 135 elderly patients with SAB admitted to two tertiary medical centers from January 2003 until December 2004. Patients were stratified into two groups: those with a 7-day post-SAB mean blood glucose < 170 mg/dL and those with a 7-day post-SAB mean blood glucose > or = 170 mg/dL. A stepwise logistic regression analysis was performed to determine whether the degree of hyperglycemia was a significant predictor of mortality. RESULTS: Seventy-four (54.8%) patients had methicillin-resistant Staphylococcus aureus bacteremia. During the follow-up period from admission until discharge, 36 (26.7%) patients died. Twenty-one (21.4%) of 98 patients with a 7-day post-SAB mean blood glucose < 170 mg/dL died, while 15 (40.5%) of 37 patients with a 7-day post-SAB mean blood glucose > or = 170 mg/dL expired. Multivariate analysis identified 3 independent determinants of death: Simplified Acute Physiology Score (SAPS) score at onset of SAB > 45 (OR 5.3, 95% CI {1.8, 15.5}, P = 0.002), a 7-day post-SAB mean blood glucose > or = 170 mg/dL (OR 3.3, 95% CI {1.2, 9.2}, P = 0.03), and altered mental status at the onset of SAB (OR 7.8, 95% CI {2.5, 23.9}, P = 0.0003). CONCLUSIONS: Hyperglycemia is an important marker of increased mortality among hospitalized elderly patients with SAB. |
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Authors:
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Mazen S Bader |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 100 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-04-02 Completed Date: 2007-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 252-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK , USA. msbader1@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bacteremia / mortality* Blood Glucose / analysis Cohort Studies Female Follow-Up Studies Hemoglobin A, Glycosylated / analysis Hospital Mortality Humans Hyperglycemia / blood, mortality* Male Methicillin Resistance Middle Aged Oklahoma / epidemiology Patient Admission Patient Discharge Retrospective Studies Risk Factors Staphylococcal Infections / mortality* Staphylococcus aureus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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