Document Detail

Hyperglycemia induced by megestrol acetate in a patient with AIDS.
MedLine Citation:
PMID:  8893118     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of hyperglycemia induced by megestrol acetate in a patient with AIDS. CASE SUMMARY: A 28-year-old man with AIDS developed hyperglycemia requiring insulin therapy 5 days after beginning megestrol therapy. The hyperglycemia resolved with discontinuation of the agent and treatment with insulin, and recurred 2 years later, when megestrol acetate treatment was rechallenged. In this case the patient had developed hyperglycemia and pancreatitis 1 year before, related to pentamidine therapy. DISCUSSION: To our knowledge this is the first reported case of hyperglycemia that was induced by megestrol acetate as early as 5 days after beginning therapy and confirmed by rechallenge. The mechanism of action is unclear. CONCLUSIONS: Clinicians caring for patients with AIDS-related cachexia should be aware that megestrol acetate can cause a severe but reversible hyperglycemic state.
L Gonzalez Del Valle; A Herrero Ambrosio; P Martinez Hernandez; B Garcia Diaz; E Jimenez Caballero
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  30     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-01-22     Completed Date:  1997-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1113-4     Citation Subset:  IM; X    
Pharmacy Department, Hospital La Paz, Madrid, Spain.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*
Cachexia / drug therapy,  etiology
Hyperglycemia / chemically induced*
Megestrol Acetate / adverse effects*
Reg. No./Substance:
51154-23-5/Megestrol Acetate

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