| Hyperglycemia and arterial stiffness: The Atherosclerosis Risk in the Communities study. | |
| | |
MedLine Citation:
|
PMID: 23031361 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Hyperglycemia has been associated with an increased risk of cardiovascular morbidity and mortality. Although numerous studies have demonstrated that hyperglycemia is associated with the atherosis component of atherosclerosis, limited studies have addressed the independent role of hyperglycemia in the pathophysiology of sclerotic vascular disease. We hypothesized that hyperglycemia, as assessed by hemoglobin A1c (HbA1c), would be independently associated two common indices of arterial stiffness (pressure-strain elastic modulus (Ep) and Young's elastic modulus (YEM)). METHODS: We examined the cross-sectional association between HbA1c and arterial stiffness using B-mode ultrasound examination of the carotid artery in 9050 participants from the community-based Atherosclerosis Risk in Communities (ARIC) study. We used multivariable linear and logistic regression models to characterize the association between HbA1c and increased Ep and YEM. RESULTS: Higher values of HbA1c were associated in a graded fashion with increased arterial stiffness (P-trend < 0.001 for both EP and YEM). After adjusting for traditional risk factors, increasing HbA1c deciles were significantly associated with elevated EP (OR for the highest decile of HbA1c compared to the lowest, 2.01, 95% CI: 1.30, 3.11) and YEM (OR = 1.71, 95% CI: 1.15, 2.55). CONCLUSION: Elevated HbA1c is associated with measures of increased arterial stiffness, even after accounting for arterial wall thickness. This is consistent with the hypothesis that hyperglycemia contributes to arterial stiffness beyond its effects on atherosis and suggests that hyperglycemia is associated with altered material within the arterial wall. |
| | |
Authors:
|
Jonathan Rubin; Vijay Nambi; Lloyd E Chambless; Michael W Steffes; Stephen P Juraschek; Josef Coresh; A Richey Sharrett; Elizabeth Selvin |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: jrubink1@jhmi.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE pat...
Next Document: Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome.