Document Detail


Hyperglycemia and arterial stiffness: the Atherosclerosis Risk in the Communities study.
MedLine Citation:
PMID:  23031361     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Hyperglycemia has been associated with an increased risk of cardiovascular morbidity and mortality. Although numerous studies have demonstrated that hyperglycemia is associated with the atherosis component of atherosclerosis, limited studies have addressed the independent role of hyperglycemia in the pathophysiology of sclerotic vascular disease. We hypothesized that hyperglycemia, as assessed by hemoglobin A1c (HbA1c), would be independently associated two common indices of arterial stiffness (pressure-strain elastic modulus (Ep) and Young's elastic modulus (YEM)).
METHODS: We examined the cross-sectional association between HbA1c and arterial stiffness using B-mode ultrasound examination of the carotid artery in 9050 participants from the community-based Atherosclerosis Risk in Communities (ARIC) study. We used multivariable linear and logistic regression models to characterize the association between HbA1c and increased Ep and YEM.
RESULTS: Higher values of HbA1c were associated in a graded fashion with increased arterial stiffness (P-trend < 0.001 for both EP and YEM). After adjusting for traditional risk factors, increasing HbA1c deciles were significantly associated with elevated EP (OR for the highest decile of HbA1c compared to the lowest, 2.01, 95% CI: 1.30, 3.11) and YEM (OR = 1.71, 95% CI: 1.15, 2.55).
CONCLUSION: Elevated HbA1c is associated with measures of increased arterial stiffness, even after accounting for arterial wall thickness. This is consistent with the hypothesis that hyperglycemia contributes to arterial stiffness beyond its effects on atherosis and suggests that hyperglycemia is associated with altered material within the arterial wall.
Authors:
Jonathan Rubin; Vijay Nambi; Lloyd E Chambless; Michael W Steffes; Stephen P Juraschek; Josef Coresh; A Richey Sharrett; Elizabeth Selvin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-13
Journal Detail:
Title:  Atherosclerosis     Volume:  225     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-11     Revised Date:  2014-03-09    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / physiopathology*
Carotid Artery, Common / ultrasonography
Carotid Intima-Media Thickness
Elastic Modulus
Female
Hemoglobin A, Glycosylated
Humans
Hyperglycemia / physiopathology*
Male
Middle Aged
Vascular Stiffness*
Grant Support
ID/Acronym/Agency:
HHSN268201100005C/HL/NHLBI NIH HHS; HHSN268201100006C/HL/NHLBI NIH HHS; HHSN268201100007C/HL/NHLBI NIH HHS; HHSN268201100008C/HL/NHLBI NIH HHS; HHSN268201100009C/HL/NHLBI NIH HHS; HHSN268201100010C/HL/NHLBI NIH HHS; HHSN268201100011C/HL/NHLBI NIH HHS; HHSN268201100012C/HL/NHLBI NIH HHS; K01 DK076595/DK/NIDDK NIH HHS; K01 DK076595/DK/NIDDK NIH HHS; R01 DK076770/DK/NIDDK NIH HHS; R21 DK080294/DK/NIDDK NIH HHS; R21 DK080294/DK/NIDDK NIH HHS; R21HL092344-01A1/HL/NHLBI NIH HHS; T32 HL007024/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated
Comments/Corrections

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