| Hyperglycemia and Death in Cystic Fibrosis-Related Diabetes. | |
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MedLine Citation:
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PMID: 21593303 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE Diabetes is common in cystic fibrosis and increases the risk of death, yet the role of hyperglycemia remains unproven. An association between glycemia and mortality would provide compelling evidence to support glucose lowering in cystic fibrosis-related diabetes (CFRD). RESEARCH DESIGN AND METHODS Using the U.K. Cystic Fibrosis Registry, we analyzed longitudinal data from 2006 to 2009 in 520 individuals with diabetes. We tested the association between HbA(1c) and mortality. RESULTS During a median follow-up of 2 years, 36 patients died. The median value of HbA(1c) was higher in those who died (7.3%) than in those who did not (6.7%). An HbA(1c) value of ≥6.5% was associated with a threefold increased risk of death (hazard ratio 3.2 [95% CI 1.4-7.3]; P = 0.005) independent of potential confounders. CONCLUSIONS Hyperglycemia trebles the risk of death in patients with CFRD. These findings provide epidemiologic support for continued efforts to improve glycemic control. |
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Authors:
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Amanda I Adler; Brian Shine; Charles Haworth; Lalantha Leelarathna; Diana Bilton |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-18 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Wolfson Diabetes and Endocrine Clinic, Addenbrooke's Hospital, Cambridge, U.K. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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