| Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Associations of maternal A1C and glucose with pregnancy outcomes. | |
| | |
MedLine Citation:
|
PMID: 22301123 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVETo compare associations of maternal glucose and A1C with adverse outcomes in the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and determine, based on those comparisons, if A1C measurement can provide an alternative to an oral glucose tolerance test (OGTT) in pregnant women.RESEARCH DESIGN AND METHODSEligible pregnant women underwent a 75-g OGTT at 24-32 weeks' gestation. A sample for A1C was also collected. Neonatal anthropometrics and cord serum C-peptide were measured. Associations with outcomes were assessed using multiple logistic regression with adjustment for potential confounders.RESULTSAmong 23,316 HAPO Study participants with glucose levels blinded to caregivers, 21,064 had a nonvariant A1C result. The mean ± SD A1C was 4.79 ± 0.40%. Associations were significantly stronger with glucose measures than with A1C for birth weight, sum of skinfolds, and percent body fat >90th percentile and for fasting and 1-h glucose for cord C-peptide (all P < 0.01). For example, in fully adjusted models, odds ratios (ORs) for birth weight >90th percentile for each measure higher by 1 SD were 1.39, 1.45, and 1.38, respectively, for fasting, 1-, and 2-h plasma glucose and 1.15 for A1C. ORs for cord C-peptide >90th percentile were 1.56, 1.45, and 1.35 for glucose, respectively, and 1.32 for A1C. ORs were similar for glucose and A1C for primary cesarean section, preeclampsia, and preterm delivery.CONCLUSIONSOn the basis of associations with adverse outcomes, these findings suggest that A1C measurement is not a useful alternative to an OGTT in pregnant women. |
| | |
Authors:
|
Lynn P Lowe; Boyd E Metzger; Alan R Dyer; Julia Lowe; David R McCance; Terence R J Lappin; Elisabeth R Trimble; Donald R Coustan; David R Hadden; Moshe Hod; Jeremy J N Oats; Bengt Persson; |
Related Documents
:
|
8229943 - Results of 527 controlled artificial inseminations in dogs. 22555133 - Pregnancy outcomes among solid organ transplant recipients in british columbia. 9830653 - Fibrinogen/fibrin and fibronectin in the dentin-pulp complex after cavity preparation i... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
|
Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Glycemic Control on Sudomotor Denervation in Type 2 Diabetes.
Next Document: Age-Related Loss of Brain Volume and T2 Relaxation Time in Youth With Type 1 Diabetes.