| The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus. | |
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MedLine Citation:
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PMID: 20510967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome. Increases in each of the 3 values on the 75-g, 2-hour oral glucose tolerance test are associated with graded increases in the likelihood of pregnancy outcomes such as large for gestational age, cesarean section, fetal insulin levels, and neonatal fat content. Based upon an iterative process of decision making, a task force of the International Association of Diabetes and Pregnancy Study Groups recommends that the diagnosis of gestational diabetes be made when any of the following 3 75-g, 2-hour oral glucose tolerance test thresholds are met or exceeded: fasting 92 mg/dL, 1-hour 180 mg/dL, or 2 hours 153 mg/dL. Various authoritative bodies around the world are expected to deliberate the adoption of these criteria. |
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Authors:
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Donald R Coustan; Lynn P Lowe; Boyd E Metzger; Alan R Dyer; |
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Publication Detail:
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Type: Journal Article; Practice Guideline; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-22 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 654.e1-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Women & Infants Hospital of Rhode Island, Providence, RI, USA. dcoustan@wihri.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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analysis* Diabetes, Gestational / diagnosis*, drug therapy Female Glucose Tolerance Test Humans Insulin / therapeutic use Odds Ratio Predictive Value of Tests Pregnancy Pregnancy Outcome |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00048/RR/NCRR NIH HHS; M01-RR00080/RR/NCRR NIH HHS; R01 HD034242-01A2/HD/NICHD NIH HHS; R01 HD034243-01A2/HD/NICHD NIH HHS; R01 HD034243-02/HD/NICHD NIH HHS; R01 HD034243-03/HD/NICHD NIH HHS; R01 HD034243-04/HD/NICHD NIH HHS; R01 HD034243-05/HD/NICHD NIH HHS; R01 HD034243-06/HD/NICHD NIH HHS; R01 HD034243-07/HD/NICHD NIH HHS; R01 HD034243-08/HD/NICHD NIH HHS; R01 HD034243-09/HD/NICHD NIH HHS; R01-HD34242/HD/NICHD NIH HHS; R01-HD34243/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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