| Hyperglycaemia and the vessel wall: the pathophysiological aspects on the atherosclerotic burden in patients with diabetes. | |
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MedLine Citation:
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PMID: 20489415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Large randomised studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both microvascular and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory'. Furthermore, evidence suggests that 'glucose variability' may also be an independent risk factor for cardiovascular complications in diabetes. Studies suggest that all these different situations of hyperglycaemia share a common pathogenetic mechanism, increased oxidative stress, producing an endothelial dysfunction. The therapeutic challenge derived from these evidences is a need not only for an early tight glycaemic control, but also for maintaining glycaemia within a strict normal narrow range. |
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Authors:
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Antonio Ceriello |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 17 Suppl 1 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: S15-9 Citation Subset: IM |
Affiliation:
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Insititut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. aceriell@clinic.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Atherosclerosis
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blood,
etiology,
physiopathology*,
prevention & control Blood Glucose / metabolism* Blood Vessels / metabolism, physiopathology* Cardiovascular Diseases / blood, etiology, physiopathology*, prevention & control Diabetic Angiopathies / blood, etiology, physiopathology*, prevention & control Evidence-Based Medicine Humans Hyperglycemia / blood, complications, physiopathology*, therapy Oxidative Stress Risk Assessment Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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