| Hyperglycaemia is negatively associated with systemic and cerebral oxygen transport in neonates after the Norwood procedure. | |
| | |
MedLine Citation:
|
PMID: 21771385 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Hyperglycaemia has been identified as a risk factor for adverse outcomes in critically ill patients, including those who have undergone cardiopulmonary bypass. Tight glucose control with insulin therapy has been shown to improve outcomes, but is not common practice for children following cardiopulmonary bypass. We examined the relationship between blood glucose level and systemic and cerebral oxygen transport in a uniform group of neonates after the Norwood procedure. METHODS: Systemic oxygen consumption was measured using respiratory mass spectrometry in 17 neonates for 72 hours postoperatively. Cardiac output, systemic and total pulmonary vascular resistances - including the Blalock-Taussig shunt, systemic oxygen delivery and oxygen extraction ratio, as well as arterial lactate and glucose, were measured at 2- to 4-hour intervals. Cerebral oxygen saturation was measured by near-infrared spectroscopy. RESULTS: Blood glucose levels ranged from 2.8 to 24.6 millimoles per litre. Elevated glucose level showed a significant negative correlation with cardiac output (p = 0.02) and cerebral oxygen saturation (p = 0.03), and a positive correlation with oxygen extraction ratio (p = 0.03). It tended to correlate positively with systemic vascular resistance (p = 0.09) and negatively with oxygen delivery (p = 0.09), but did not correlate with oxygen consumption (p = 0.13). CONCLUSIONS: Hyperglycaemia is negatively associated with systemic haemodynamics, oxygen transport, and cerebral oxygenation status in neonates after the Norwood procedure. Further study is warranted to examine tight glucose control with insulin therapy on postoperative systemic and cerebral oxygen transport and functional outcomes in neonates after cardiopulmonary bypass. |
| | |
Authors:
|
Gencheng Zhang; Sally Cai; Jia Li |
Related Documents
:
|
21386205 - Extra-oral halitosis: an overview. 18034305 - Electroosmotic flow and particle transport in micro/nano nozzles and diffusers. 10686375 - One-dimensional solute transport in stratified sands at short travel distances. 10474655 - Low reynolds number turbulence modeling of blood flow in arterial stenoses. 14597345 - The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in ... 6654465 - Systemic and arterial hemodynamic effects of nifedipine (20 mg) in mild-to-moderate hyp... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
|
Title: Cardiology in the young Volume: - ISSN: 1467-1107 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: - |
Other Details:
|
Languages: ENG Pagination: 1-8 Citation Subset: - |
Affiliation:
|
1The Labbatt Family Heart Centre, Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The sinister course of an intramural right coronary artery.
Next Document: Multifrequency Atomic Force Microscopy: Compositional Imaging with Electrostatic Force Measurements.