| Hyperglobulinemia in amiodarone-induced pneumonitis. | |
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MedLine Citation:
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PMID: 17357845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amiodarone is a very effective antiarrhytmic drug. However its use may be accompanied by side effects. Hyperglobulinemia was not described in association with amiodarone treatment. MATERIALS AND METHODS: Fifteen patients, who developed hyperglobulinemia while on amiodarone therapy, were identified among the patients hospitalized in our hospital. Serum globulin concentration was measured prior to, during and after amiodarone therapy. RESULTS: In 11 of the 15 patients with amiodarone-associated hyperglobulinemia, amiodarone treatment had to be stopped because of amiodarone-induced complications, nine of them had pneumonitis. Mean serum globulin level rose during amiodarone therapy from 2.48 +/- 0.51 g/dL to 4.11 +/- 0.71 g/dL (p = 0.001), and declined after it was stopped to 2.80 +/- 0.49 g/dL (p = 0.001). In 50 patients treated by amiodarone, serum globulin was similar to that found in 50 patients with ischemic heart disease not treated by amiodarone [2.64 +/- 0.39 g/dL and 2.56 +/- 0.29 g/dL respectively (p = 0.21)]. CONCLUSIONS: In some patients amiodarone therapy may be associated with hyperglobulinemia. The incidence of this association is not known. Most of the patients with amiodarone-associated hyperglobulinemia have amiodarone-induced toxicity, mainly pneumonitis. Amiodarone therapy does not cause a general increase in serum globulins. Hyperglobulinemia may be a marker for a damaged organ, or it may have a pathogenetic role in the induction of pneumonitis. |
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Authors:
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Meir Mouallem; Natalia Antipov; Haim Mayan; Ben Ami Sela; Zvi Farfel |
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Publication Detail:
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Type: Journal Article Date: 2007-03-15 |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 21 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-04-16 Completed Date: 2007-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM |
Affiliation:
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Department of Medicine E, Sheba medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer, 52621, Israel. mouallem@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Amiodarone / adverse effects*, therapeutic use Anti-Arrhythmia Agents / adverse effects, therapeutic use Coronary Artery Disease / blood, drug therapy Female Humans Inpatients Kidney Failure, Chronic / blood, drug therapy Male Middle Aged Pneumonia / blood*, chemically induced* Serum Globulins / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Serum Globulins; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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