Document Detail


Hyperfractionated radiation in combination with local hyperthermia in the treatment of advanced squamous cell carcinoma of the head and neck: a phase I-II study.
MedLine Citation:
PMID:  9424006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-seven patients with cervical metastases from squamous cell head and neck tumours were treated with hyperfractionated XRT (total dose 69.60-76.80 Gy, 1.2 Gy b.i.d. five times a week) combined with a total of two to six sessions of superficial external HT. Acute local toxicity was mild; as major acute side effects, only one ulceration was recorded. No severe late side effects were observed. Late toxicity was similar to that observed in our previous studies with the combination of heat and radiation. Nodal complete response was observed in 77% of patients, partial response was observed in 15% of patients and no change was observed in 8% of patients. Five-year actuarial nodal control was 64.5 +/- 19% and 5-year actuarial survival was 24 +/- 10%. The treatment of nodal metastases from head and neck tumours with the combination of HT and hyperfractionated XRT is feasible with an acceptable acute and late toxicity profile.
Authors:
M Amichetti; M Romano; L Busana; A Bolner; G Fellin; G Pani; L Tomio; R Valdagni
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  45     ISSN:  0167-8140     ISO Abbreviation:  Radiother Oncol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-28     Completed Date:  1998-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, St. Chiara Hospital, Trento, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Squamous Cell / mortality,  pathology,  therapy*
Combined Modality Therapy
Dose Fractionation
Feasibility Studies
Female
Head and Neck Neoplasms / mortality,  pathology,  therapy*
Humans
Hyperthermia, Induced*
Lymphatic Metastasis / pathology,  radiotherapy
Male
Middle Aged
Neoplasm Recurrence, Local
Pilot Projects
Radiation Dosage
Radiotherapy, High-Energy*
Survival Rate
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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