Document Detail


Hyperfibrinogenemia and hyperviscous plasma in hypertensive Africans.
MedLine Citation:
PMID:  1476270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in plasma fibrinogen concentrations (PFC) and relative plasma viscosity (RPV) were investigated in 61 Nigerian Africans while they were being treated for essential hypertension. The association of these hemorheologic variables with blood pressure was examined. An analogous study was done on 30 normotensive controls for comparison. The hypertensive patients had, overall, a significant increase in both PFC and RPV (p < 0.001) as compared with control values. However, 44.3% of the hypertensive patients had PFC and RPV values within the defined normal limits. This indicates that in a proportion of the hypertensives, treatment notwithstanding, PFC and RPV are altered only within the physiologic limits. Comparison of PFC and RPV with the degree of hypertension (mild: diastolic blood pressure (DBP) = 90mmHg; moderate: DBP = 91-99mmHg; severe: DBP > or = 100mmHg) showed significant stepwise increases at the moderate and severe levels as compared with the mild level of hypertension. The hyperfibrinogenemia and concomitant hyperviscous plasma observed in the present study could either play a role in the pathogenesis of the hypertension or be the consequence of the hypertension itself, at least in some patients.
Authors:
H L Reid; L I Ojogwu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  43     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-02-03     Completed Date:  1993-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  826-32     Citation Subset:  IM    
Affiliation:
Department of Physiology, College of Medical Sciences, School of Medicine, University of Benin, Nigeria, West Africa.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group*
Aged
Aged, 80 and over
Blood Pressure
Blood Viscosity*
Female
Fibrinogen / analysis*
Humans
Hypertension / blood*,  physiopathology
Male
Middle Aged
Nigeria
Chemical
Reg. No./Substance:
9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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