Document Detail

Hyperfamiliarity for faces.
MedLine Citation:
PMID:  20308681     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report 4 cases of hyperfamiliarity for faces (HFF) and review 5 previously reported cases.
METHODS: We identified cases of HFF from PubMed search and references in prior reports.
RESULTS: Three of our 4 cases had pathologic findings that were most extensive in the left temporal lobe. HFF occurred after a tonic-clonic seizure (cases 1 and 3), during simple partial seizures (case 2), and in the setting of an increase in simple partial seizure frequency but not during seizures (case 4). All 9 cases were adults with 1 or more seizures; symptoms first occurred after seizures in 5 cases and during seizures in 1 case. Ictal symptoms lasted from seconds to minutes and from 2 days to more than 7 years in the other 6 cases. The duration of HFF was not associated with the presence or extent of a structural lesion. While in several cases HFF appears to result from a postictal Todd paralysis, the mechanism underlying persistent cases is uncertain.
CONCLUSIONS: This modality (visual)-specific and stimulus (face)-specific syndrome is associated with diverse structural, functional imaging, and neurophysiologic findings. Lesions are more often left-sided and involve the temporal lobe. Epilepsy and seizures were present in all 9 cases, suggesting a pathophysiologic relationship, which likely varies among cases. Although only reported in 9 patients, HFF is probably much more common than it is diagnosed.
O Devinsky; L Davachi; C Santchi; B T Quinn; B P Staresina; T Thesen
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  74     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-06     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  970-4     Citation Subset:  AIM; IM    
Department of Neurology, NYU Langone School of Medicine, New York, NY, USA.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / diagnosis,  etiology*
Cognition Disorders / diagnosis,  etiology*
Epilepsy, Tonic-Clonic / complications*
Magnetic Resonance Imaging
Memory Disorders / etiology*,  pathology
Middle Aged
Neuropsychological Tests
Parahippocampal Gyrus / pathology
Pattern Recognition, Physiological
Recognition (Psychology)
Temporal Lobe / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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