Document Detail

Hypereosinophilic syndrome and myocardial infarction in a 15-year-old.
MedLine Citation:
PMID:  9185225     Owner:  NLM     Status:  MEDLINE    
The hypereosinophilic syndrome (HES) is a rare yet frequently fatal disorder of unknown etiology characterized by markedly elevated eosinophil counts and subsequent multiple organ failure due presumably to eosinophil-derived protein toxicity. We describe the laboratory and anatomic findings in a 15-year-old female with extraordinarily high circulating levels of eosinophil major basic protein (MBP) who sustained a precipitous cardiac death secondary to a massive myocardial infarction. Postmortem examination showed marked cardiomegaly with extensive recent left ventricular infarction. Occlusive thrombosis of small blood vessels was evident in the myocardium, spleen, lungs, and kidneys. Immunofluorescent staining showed massive MBP deposition in multiple organ parenchyma including the heart, renal glomeruli, adrenal cortex, bronchioles, and other visceral organs, suggesting a causal relationship. We hypothesize on the mechanisms of eosinophil toxicity in HES.
A E Rauch; K M Amyot; H G Dunn; B Ng; G Wilner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association     Volume:  17     ISSN:  1077-1042     ISO Abbreviation:  Pediatr Pathol Lab Med     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-08-22     Completed Date:  1997-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9518033     Medline TA:  Pediatr Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-86     Citation Subset:  IM    
Division of Hematology, Albany Medical College, New York 12208, USA.
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MeSH Terms
Blood Proteins / metabolism
Brain / pathology
Eosinophil Granule Proteins
Fatal Outcome
Hypereosinophilic Syndrome / blood,  complications*,  pathology*
Liver / pathology
Lung / pathology
Magnetic Resonance Imaging
Multiple Organ Failure / complications,  pathology
Myocardial Infarction / complications*,  pathology
Myocardium / pathology
Spleen / pathology
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

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