| Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI. | |
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MedLine Citation:
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PMID: 18310508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial spin labeling (ASL) is a noninvasive magnetic resonance imaging (MRI) technique for microvascular blood flow measurement. We used a continuous ASL scheme (CASL) to investigate the hyperemic flow difference between major muscle groups in human extremities. Twenty-four healthy subjects with no evidence of vascular disease were recruited. MRI was conducted on a 3.0 Tesla Siemens Trio whole body system with a transmit/receive knee coil. A nonmagnetic orthopedic tourniquet system was used to create a 5-min period of ischemia followed by a period of hyperemic flow (occlusion pressure = 250 mmHg). CASL imaging, lasting from 2 min before cuff inflation to 3 min after cuff deflation, was performed on the midcalf, midfoot, and midforearm in separate sessions from which blood flow was quantified with an effective temporal resolution of 16 s. When muscles in the same anatomic location were compared, hyperemic flow was found to be significantly higher in the compartments containing muscles known to have relatively higher slow-twitch type I fiber compositions, such as the soleus muscle in the calf and the extensors in the forearm. In the foot, the plantar flexors exhibited a slightly delayed hyperemic response relative to that of the dorsal compartment, but no between-group flow difference was observed. These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance. |
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Authors:
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Wen-Chau Wu; Jiongjiong Wang; John A Detre; Felix W Wehrli; Emile Mohler; Sarah J Ratcliffe; Thomas F Floyd |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2008-02-29 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 294 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-07 Completed Date: 2008-06-12 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2129-36 Citation Subset: IM |
Affiliation:
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Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arteries / physiopathology Blood Flow Velocity Female Foot / blood supply* Forearm / blood supply* Humans Hyperemia / pathology, physiopathology* Leg / blood supply* Magnetic Resonance Imaging / methods* Male Middle Aged Models, Cardiovascular Muscle Fibers, Skeletal / pathology Muscle, Skeletal / blood supply*, pathology Regional Blood Flow Spin Labels* Time Factors Tourniquets |
| Grant Support | |
ID/Acronym/Agency:
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5P41 RR 002305/RR/NCRR NIH HHS; 5R01 HL 075649-05/HL/NHLBI NIH HHS; R01 HL075649-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
| Comments/Corrections | |
Erratum In:
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Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H902 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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