Document Detail


Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI.
MedLine Citation:
PMID:  18310508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial spin labeling (ASL) is a noninvasive magnetic resonance imaging (MRI) technique for microvascular blood flow measurement. We used a continuous ASL scheme (CASL) to investigate the hyperemic flow difference between major muscle groups in human extremities. Twenty-four healthy subjects with no evidence of vascular disease were recruited. MRI was conducted on a 3.0 Tesla Siemens Trio whole body system with a transmit/receive knee coil. A nonmagnetic orthopedic tourniquet system was used to create a 5-min period of ischemia followed by a period of hyperemic flow (occlusion pressure = 250 mmHg). CASL imaging, lasting from 2 min before cuff inflation to 3 min after cuff deflation, was performed on the midcalf, midfoot, and midforearm in separate sessions from which blood flow was quantified with an effective temporal resolution of 16 s. When muscles in the same anatomic location were compared, hyperemic flow was found to be significantly higher in the compartments containing muscles known to have relatively higher slow-twitch type I fiber compositions, such as the soleus muscle in the calf and the extensors in the forearm. In the foot, the plantar flexors exhibited a slightly delayed hyperemic response relative to that of the dorsal compartment, but no between-group flow difference was observed. These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance.
Authors:
Wen-Chau Wu; Jiongjiong Wang; John A Detre; Felix W Wehrli; Emile Mohler; Sarah J Ratcliffe; Thomas F Floyd
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-02-29
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  294     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-06-12     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2129-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteries / physiopathology
Blood Flow Velocity
Female
Foot / blood supply*
Forearm / blood supply*
Humans
Hyperemia / pathology,  physiopathology*
Leg / blood supply*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Models, Cardiovascular
Muscle Fibers, Skeletal / pathology
Muscle, Skeletal / blood supply*,  pathology
Regional Blood Flow
Spin Labels*
Time Factors
Tourniquets
Grant Support
ID/Acronym/Agency:
5P41 RR 002305/RR/NCRR NIH HHS; 5R01 HL 075649-05/HL/NHLBI NIH HHS; R01 HL075649/HL/NHLBI NIH HHS; R01 HL075649-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Spin Labels
Comments/Corrections
Erratum In:
Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H902

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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