Document Detail

Hyperemesis gravidarum and fetal outcome.
MedLine Citation:
PMID:  15772386     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperemesis gravidarum (HG) is reported in 0.5-2% of all pregnancies. The purpose of this research was to evaluate the relationship of maternal HG, neonatal birth weight, and birth outcomes. METHODS: This is a prospective cohort study of 45 patients diagnosed, by Fairweather's criteria, with HG compared with 306 non-HG control pregnant patients with singleton pregnancies. Sociodemographic and clinical data were obtained from the pregnant patients. Neonatal data were also collected, including indicators of neonatal wellness. RESULTS: Significantly higher incidences of being nonwhite (33% vs 16%; p < .05) and of attaining post-high school education (60% vs 38%) were noted in the HG group, relative to controls. Mothers in the control group experienced greater gestational weight gain, 14.9 +/- 0.3 kg (mean +/- SEM) relative to mothers in the HG group (10.6 +/- 1.3 kg). Infants from HG pregnancies manifested significantly lower birth weight (3.23 +/- 0.09 kg vs 3.52 +/- 0.03 kg), younger gestational age (38.4 +/- 0.3 weeks vs 39.7 +/- 0.1 weeks), and a greater length of hospital stay (2.9 +/- 0.5 days vs 1.8 +/- 0.1 day), relative to infants from the control group. After undergoing multivariate analysis, HG was a significant predictor of decreased gestational age and increased hospital length of stay. CONCLUSIONS: Infants born of women who had HG are more likely to experience decreased gestational age and increased length of hospital stay. Efficacy of early and aggressive treatment of HG, including nutrition support, in minimizing these outcomes needs to be studied.
James D Paauw; Sandra Bierling; Curtis R Cook; Alan T Davis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  29     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-03-17     Completed Date:  2005-09-01     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Spectrum Health Nutrition Support Service, Grand Rapids, MI 49503, USA.
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MeSH Terms
Apgar Score
Birth Weight / physiology*
Case-Control Studies
Cohort Studies
Continental Population Groups
Educational Status
Gestational Age*
Hyperemesis Gravidarum / physiopathology*
Infant, Newborn
Length of Stay
Multivariate Analysis
Pregnancy Outcome*
Prospective Studies
Weight Gain*
Comment In:
JPEN J Parenter Enteral Nutr. 2005 Mar-Apr;29(2):134-5   [PMID:  15772393 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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