Document Detail

Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey.
MedLine Citation:
PMID:  7046476     Owner:  NLM     Status:  MEDLINE    
A new model of high cardiac output septic shock in primates is presented that includes hemodynamic and metabolic effects of separate and combined infusions of normal saline and live Escherichia coli. In monkeys receiving ketamine anesthesia, cardiac output (QT) increased with saline loading but not significantly with bacterial infusion, and bacterial infusion without saline never significantly increased QT. Depressed oxygen consumption (VO2) was reversed with saline loading. In spite of continuing E. coli infusion, radiolabeled microspheres showed no increase in systemic anatomic shunt when QT was elevated. It is perceived that the tissue dysfunction associated with sepsis, which is called septic shock, and elevation of cardiac output are related only indirectly. High cardiac output only reflects an adequate volume status in a stressed individual; some of the afferent stress signals can be related to the septic state, but no specific or direct relationship is involved. In general, shock as indicated by a depression of VO2 does not appear to occur when QT is increased.
G C Carroll; J V Snyder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R131-41     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Coronary Circulation
Escherichia coli Infections / physiopathology*
Fluid Therapy*
Heart / physiopathology*
Kidney / blood supply
Lactates / blood
Lung / blood supply
Macaca fascicularis
Muscles / blood supply
Oxygen Consumption
Regional Blood Flow
Shock, Septic / physiopathology*,  therapy
Skin / blood supply
Sodium Chloride / therapeutic use
Reg. No./Substance:
0/Lactates; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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