| Hyperdynamic sepsis in baboons: I. Aspects of hemodynamics. | |
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MedLine Citation:
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PMID: 1884434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The baboon has a number of advantages as a shock model, as its physiological as well as its biochemical behaviour is similar to man. Therefore we have tried to set up a model to mimic the early hyperdynamic phase of clinical sepsis. Seven baboons, 21-25 kg body weight were kept under EEG servocontrolled anesthesia for 8 hr. During this time live E. coli (ATC #33985) 2 x 10(10) BW/8 hr were continuously infused intravenously. Adequate fluid supply with Ringer's solution (up to 40 ml/kg/hr) was given to keep the pulmonary artery wedge pressure at baseline levels; this procedure resulted in a hyperdynamic response with a cardiac output (CO) 20-35% above baseline and a decrease (20-39%) in mean arterial pressure (MAP), leading to a 50% decrease in peripheral resistance. The pulmonary vascular changes were reflected in an increase of the mean pulmonary pressure (PA) to 42% above baseline and a marked rise in pulmonary vascular resistance (PVR) to 50% above baseline with no additional changes in pulmonary gas exchange. After 8 hr both CO and MAP were inversely correlated (r = 0.9-1) with dramatically increased catecholamine plasma levels (15 times above baseline). With continuous infusion of live E. coli (blood levels 10(5)-10(6) CFU/ml) and massive fluid supply we have successfully mimicked hyperdynamic sepsis with severe organ failure after an 8-hr observation period. |
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Authors:
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G Schlag; H Redl; S Hallström; K Radmore; J Davies |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulatory shock Volume: 34 ISSN: 0092-6213 ISO Abbreviation: Circ. Shock Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-04 Completed Date: 1991-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0414112 Medline TA: Circ Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 311-8 Citation Subset: IM |
Affiliation:
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Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiac Output Colony Count, Microbial Escherichia coli Infections / blood, microbiology, physiopathology* Hemodynamics* Leukocyte Count Male Oxygen / blood |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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