Document Detail

Hyperdopaminergia in schizophreniform psychosis: a chronobiological study.
MedLine Citation:
PMID:  8341771     Owner:  NLM     Status:  MEDLINE    
Circadian rhythm abnormalities have been described in various psychiatric disorders, but they have not received much attention in studies of schizophrenia and schizophreniform psychosis. The present study used the cosine model to determine the circadian patterns of amino acids, dopamine, and prolactin concentrations, which were analyzed over a 24-hour period in serum of healthy subjects, drug-free schizophrenic patients, and neuroleptic-treated schizophrenic patients. The mesor (the daily mean) of phenylalanine was lower in drug-free schizophrenic women than in healthy women. The mesors of the ratio of phenylalanine or tyrosine to competing amino acids were similar in healthy subjects and patients. The ratio of phenylalanine/competing amino acids showed a phase advance (i.e., earlier onset of the time of highest concentration) in drug-free patients compared with healthy subjects. Schizophrenic patients displayed a higher dopamine mesor than healthy subjects. Female drug-free schizophrenic patients had lower prolactin mesors and lower amplitudes (i.e., half of the total predictable change in rhythm) than healthy women. Compared with healthy subjects, schizophrenic patients showed a phase advance of circadian prolactin concentrations. Neuroleptics raised the prolactin mesor and amplitudes but did not elicit any phase change in amino acids, dopamine, or prolactin. These data confirm the indirect pharmacologic evidence of increased dopaminergic activity in schizophrenic patients that relates to dopamine's precursors and to the neuroendocrine regulation of prolactin.
M L Rao; G Gross; A Halaris; G Huber; M Marler; B Strebel; P Bräunig
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  47     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-31     Completed Date:  1993-08-31     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  187-203     Citation Subset:  IM    
Universitätsnervenklinik, Psychiatrie, Bonn, Germany.
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MeSH Terms
Amino Acids / physiology
Circadian Rhythm / physiology*
Dopamine / blood*,  physiology
Middle Aged
Prolactin / blood,  physiology
Psychotic Disorders / blood*,  drug therapy,  physiopathology
Schizophrenia / blood,  drug therapy,  physiopathology
Reg. No./Substance:
0/Amino Acids; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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