Document Detail


Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH).
MedLine Citation:
PMID:  17928884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 38 patients with acute myeloblastic leukemia (AML) with 49 or more chromosomes and without structural abnormalities was selected within the Groupe Francophone de Cytogénétique Hématologique (GFCH) to better define their characteristics. The median age of the patients was 65 years, and all FAB subtypes were represented. Although all chromosomes were gained, some seems to prevail: chromosome 8 (68%), 21 (47%), 19 (37%), and 13 and 14 (34% each). Since MLL rearrangement leads patients in a group with an unfavorable prognosis, search for cryptic rearrangements of MLL was performed in 34 patients and showed abnormalities in 5 (15%). When we applied the most frequent definition of complex karyotypes (three or more abnormalities), all patients with high hyperdiploid AML fall in the unfavorable category. Among the 18 patients without MLL rearrangement receiving an induction therapy, 16 (89%) reached CR and 6 (33%) were still alive after a 31-month median follow-up (14-61 months). Although this study was retrospective, these results suggest that high hyperdiploid AML without chromosome rearrangement seems to be a subgroup of uncommon AML (less than 1%), and may be better classified in the intermediate prognostic group.
Authors:
I Luquet; J L Laï; C Barin; L Baranger; C Bilhou-Nabera; E Lippert; C Gervais; P Talmant; P Cornillet-Lefebvre; C Perot; N Nadal; M J Mozziconacci; M Lafage-Pochitaloff; V Eclache; F Mugneret; C Lefebvre; C Herens; F Speleman; H Poirel; I Tigaud; C Cabrol; P Rousselot; S Daliphard; M Imbert; R Garand; F Geneviève; R Berger; C Terre;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2007-10-11
Journal Detail:
Title:  Leukemia     Volume:  22     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-03-06     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  132-7     Citation Subset:  IM    
Affiliation:
Department of Cytogenetic, Hôpital Robert Debré, Reims, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Chromosome Aberrations*
Chromosomes, Human / genetics*
Female
Gene Rearrangement
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid / drug therapy,  epidemiology,  genetics*
Male
Middle Aged
Myeloid-Lymphoid Leukemia Protein / genetics
Ploidies*
Prognosis
Prospective Studies
Retrospective Studies
Chemical
Reg. No./Substance:
0/MLL protein, human; 149025-06-9/Myeloid-Lymphoid Leukemia Protein

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