| Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH). | |
MedLine Citation:
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PMID: 17928884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 38 patients with acute myeloblastic leukemia (AML) with 49 or more chromosomes and without structural abnormalities was selected within the Groupe Francophone de Cytogénétique Hématologique (GFCH) to better define their characteristics. The median age of the patients was 65 years, and all FAB subtypes were represented. Although all chromosomes were gained, some seems to prevail: chromosome 8 (68%), 21 (47%), 19 (37%), and 13 and 14 (34% each). Since MLL rearrangement leads patients in a group with an unfavorable prognosis, search for cryptic rearrangements of MLL was performed in 34 patients and showed abnormalities in 5 (15%). When we applied the most frequent definition of complex karyotypes (three or more abnormalities), all patients with high hyperdiploid AML fall in the unfavorable category. Among the 18 patients without MLL rearrangement receiving an induction therapy, 16 (89%) reached CR and 6 (33%) were still alive after a 31-month median follow-up (14-61 months). Although this study was retrospective, these results suggest that high hyperdiploid AML without chromosome rearrangement seems to be a subgroup of uncommon AML (less than 1%), and may be better classified in the intermediate prognostic group. |
Authors:
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I Luquet; J L Laï; C Barin; L Baranger; C Bilhou-Nabera; E Lippert; C Gervais; P Talmant; P Cornillet-Lefebvre; C Perot; N Nadal; M J Mozziconacci; M Lafage-Pochitaloff; V Eclache; F Mugneret; C Lefebvre; C Herens; F Speleman; H Poirel; I Tigaud; C Cabrol; P Rousselot; S Daliphard; M Imbert; R Garand; F Geneviève; R Berger; C Terre; |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2007-10-11 |
Journal Detail:
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Title: Leukemia Volume: 22 ISSN: 1476-5551 ISO Abbreviation: Leukemia Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-16 Completed Date: 2008-03-06 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: England |
Other Details:
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Languages: eng Pagination: 132-7 Citation Subset: IM |
Affiliation:
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Department of Cytogenetic, Hôpital Robert Debré, Reims, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Chromosome Aberrations* Chromosomes, Human / genetics* Female Gene Rearrangement Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Myeloid / drug therapy, epidemiology, genetics* Male Middle Aged Myeloid-Lymphoid Leukemia Protein / genetics Ploidies* Prognosis Prospective Studies Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/MLL protein, human; 149025-06-9/Myeloid-Lymphoid Leukemia Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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