Document Detail


Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait.
MedLine Citation:
PMID:  19940469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Patients with thalassemia major often present with a hypercoagulable state, the pathogenesis of which is still not understood. MATERIALS AND METHODS: This study evaluates the risk factors for hypercoagulability in 50 beta-thalassemia major patients and 50 healthy controls. Fasting total homocysteine, protein C (PC), protein S (PS), antithrombin (AT), activated protein C resistance (APCR) and lupus anticoagulant (LA) were assessed. MTHFR C677T mutation was determined. RESULTS: Significant reductions in PC, PS and AT were noted in patients. Only 4% of the patients had hyperhomocysteinemia. Thirty-two percent of the patients were heterozygous and 4% were homozygous for MTHFR C677T mutation. CONCLUSION: The natural coagulation inhibitors PC, PS and AT were significantly reduced in patients with beta-thalassemia major and were thus important risk factors for the hypercoagulable state, but hyperhomocysteinemia and MTHFR mutation do not seem to be significant risk factors for thromboembolic events.
Authors:
Nada Y Mustafa; Rajaa Marouf; Salah Al-Humood; Suad M Al-Fadhli; Olusegun Mojiminiyi
Related Documents :
1138629 - Results of ankle ststolic pressure measurements in patients with intermittent claudicat...
10555699 - Manifestations of factor viii inhibitor in the head and neck.
18345709 - Recombinant factor viia (eptacog alfa): a review of its use in congenital hemophilia wi...
11460009 - Maximal endothelial tissue plasminogen activator release is not impaired in patients wi...
16695929 - The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purin...
7589679 - Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation ...
18171289 - Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria.
7617969 - The impact of chronic illness on patients.
2581639 - 5q- chromosome in acute leukemia with lymphoid morphology and expression of myeloid mem...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-21
Journal Detail:
Title:  Acta haematologica     Volume:  123     ISSN:  1421-9662     ISO Abbreviation:  Acta Haematol.     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 S. Karger AG, Basel.
Affiliation:
Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Activated Protein C Resistance / blood
Adolescent
Adult
Antithrombins / metabolism
Base Sequence
Blood Coagulation Disorders / blood*,  etiology*,  genetics
Case-Control Studies
DNA Primers / genetics
Female
Heterozygote
Homocysteine / blood
Homozygote
Humans
Kuwait
Lupus Coagulation Inhibitor / blood
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Point Mutation*
Protein C / metabolism
Protein S / metabolism
Risk Factors
Thromboembolism / blood,  etiology,  genetics
Young Adult
beta-Thalassemia / blood*,  complications,  genetics*
Chemical
Reg. No./Substance:
0/Antithrombins; 0/DNA Primers; 0/Lupus Coagulation Inhibitor; 0/Protein C; 0/Protein S; 454-28-4/Homocysteine; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Granulomatous Pneumocystis jiroveci Pneumonia in a Patient with Diffuse Large B-Cell Lymphoma: Case ...
Next Document:  Response of Coronary Heart Disease Risk Factors to Changes in Body Fat during Diet-Induced Weight Re...