Document Detail


Hypercoagulability in patients with haematological neoplasia: no apparent initiation by tissue factor.
MedLine Citation:
PMID:  18521506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with haematological malignancies carry increased risk of venous thrombosis (VT). However, the mechanisms that link these malignancies to activated coagulation have not been fully identified. Since anti-haemostatic agents are studied in clinical trials for their potential to prolong survival in cancer patients, a detailed characterisation of haemostatic markers in cancer subtypes is needed. Hence, in this study, we measured the plasma concentrations and mRNA expression in blood mononuclear cells of haemostatic parameters in 93 patients with haematological neoplasias (acute myeloid leukaemia, chronic lymphatic leukaemia, multiple myeloma, and non-Hodgkin's lymphoma) before start and after completion of cancer therapy. At diagnosis we found activation of coagulation and fibrinolysis, especially in patients with acute myeloid leukaemia. This hypercoagulation was not associated with increased levels of tissue factor (TF) or factor VII (fVII) antigen or mRNA, or levels of activated fVII. In conclusion we found a hypercoagulable state in patients with haematological malignancy that did not seem to be initiated by TF.
Authors:
Helene F S Negaard; Per Ole Iversen; Bjørn Østenstad; Nina Iversen; Pål A Holme; Per Morten Sandset
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  99     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1040-8     Citation Subset:  IM    
Affiliation:
Department of Haematology, Ullevål University Hospital Trust, Oslo, Norway. Helene.Negaard@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Blood Coagulation* / genetics
Case-Control Studies
Factor VII / metabolism
Female
Fibrin Fibrinogen Degradation Products / metabolism
Glycoproteins / blood
Hematologic Neoplasms / blood*,  complications,  genetics,  therapy
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / blood,  complications
Leukemia, Myeloid, Acute / blood,  complications
Lipoproteins / blood
Longitudinal Studies
Lymphoma, Non-Hodgkin / blood,  complications
Male
Middle Aged
Multiple Myeloma / blood,  complications
Norway
Peptide Fragments / blood
Prothrombin
RNA, Messenger / blood
Thrombophilia / blood,  etiology*,  genetics
Thromboplastin / metabolism
Venous Thrombosis / blood,  etiology*,  genetics
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/Glycoproteins; 0/Lipoproteins; 0/Peptide Fragments; 0/RNA, Messenger; 0/fibrin fragment D; 0/lipoprotein-associated coagulation inhibitor; 0/prothrombin fragment 1.2; 0/tissue-factor-pathway inhibitor 2; 9001-25-6/Factor VII; 9001-26-7/Prothrombin; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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