Document Detail

Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids.
MedLine Citation:
PMID:  8120655     Owner:  NLM     Status:  MEDLINE    
In rabbits, elevation of LDL cholesterol is produced by feeding a cholesterol-free, semipurified diet containing 30% casein amino acid mixture, but not by feeding the same diet containing 14.7% of the casein amino acid mixture, corresponding to a normal level of dietary protein. The hypercholesterolemic response was greater when all essential amino acids except arginine or all ketogenic essential amino acids (lysine, leucine, isoleucine, threonine, phenylalanine, tryptophan and glycine) were selectively fed at three times the normal level. In the present experiments, the same high levels of lysine, leucine and methionine produced a substantial hypercholesterolemia, addition of either isoleucine + threonine or isoleucine + valine did not enhance the effect, and a mixture of threonine, histidine, phenylalanine, tryptophan and glycine gave only a moderate response. A combination of lysine and methionine produced a greater effect than either lysine and leucine or leucine and methionine. Hypercholesterolemic diets containing high levels of lysine and leucine did not cause significantly greater plasma ketone bodies or free fatty acids. Differences in growth rates and ketogenic responses were not generally correlated with hypercholesterolemia.
E M Kurowska; K K Carroll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  124     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-04-05     Completed Date:  1994-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-70     Citation Subset:  IM    
Department of Biochemistry, University of Western Ontario, London, Canada.
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MeSH Terms
Amino Acids, Essential / administration & dosage*
Cholesterol / blood
Cholesterol, LDL / blood
Fatty Acids, Nonesterified / blood
Hypercholesterolemia / blood,  etiology*
Ketone Bodies / blood
Leucine / administration & dosage
Lysine / administration & dosage
Weight Gain
Reg. No./Substance:
0/Amino Acids, Essential; 0/Cholesterol, LDL; 0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 56-87-1/Lysine; 57-88-5/Cholesterol; 61-90-5/Leucine

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