| Hypercholesterolemia: Chemical Aspect of Approach. | |
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MedLine Citation:
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PMID: 21824085 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This review is the first attempt at systematization and analysis of the literature data (covering the last decade) on the chemical structures and specific activities of cholesterol-regulating agents. Six of thirty currently known biological targets for treating hyperlipidemia were selected and considered. All of the chemical structures under study are divided into two classes with different mechanisms of their activity: cholesterol biosynthesis blockers (HMG-CoA reductase and squalene 2,3-oxide-lanosterol cyclase inhibitors) and regulators of cholesterol transformations in the organism (PPARα and PPARα/γ agonists, inhibitors of intestinal absorption of cholesterol, cholesteryl ester transfer protein (CETP) inhibitors, and regulators of low-density-lipoprotein receptor (LDLR) expression). |
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Authors:
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N F Salakhutdinov; L N Rogoza; G A Tolstikov |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-9 |
Journal Detail:
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Title: Current medicinal chemistry Volume: - ISSN: 1875-533X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Vorozhtsov Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, "pr. akademika Lavrent'eva 9, Novosibirsk, 630090", Russian Federation. rogoza@nioch.nsc.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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