| Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. | |
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MedLine Citation:
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PMID: 18626629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Recent evidence demonstrated that hypercapnic acidosis due to lung protective strategy was not only permissive but also even therapeutic for injured lung. Since the effects of hypercapnic acidosis on extra-pulmonary organs remain to be clarified, we tested the hypothesis that hypercapnic acidosis protects gut mucosal barrier function by modulating inflammation in a rabbit model of endotoxemia. DESIGN: Prospective randomized animal study. SETTING: University research laboratory. SUBJECTS: Male New Zealand white rabbits. INTERVENTIONS: Thirty-two animals were randomly allocated into two groups: normocapnia (n = 17) and hypercapnia (n = 15). The latter group received F(I)CO(2) 5% under mechanical ventilation to achieve hypercapnia throughout the study periods, whereas the former with F(I)CO(2) 0%. MEASUREMENTS AND RESULTS: Arterial blood gas, intramucosal pH (pHi) and portal blood flow were assessed at baseline, 2-h and 4-h infusion of lipopolysaccharide. At 4 h, ileal myeloperoxidase (MPO) activity and intestinal permeability were measured. The animals in the hypercapnia group showed apparent hypercapnic acidosis and progressive intramucosal acidosis at 4 h, accompanied by significantly lower intestinal permeability versus normocapnia group. Ileal MPO activity was comparable between the study groups. CONCLUSIONS: Hypercapnic acidosis attenuates endotoxin-induced gut barrier dysfunction possibly through neutrophil-independent mechanisms. |
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Authors:
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Hiroshi Morisaki; Satoshi Yajima; Yoko Watanabe; Takeshi Suzuki; Michiko Yamamoto; Nobuyuki Katori; Saori Hashiguchi; Junzo Takeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-15 |
Journal Detail:
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Title: Intensive care medicine Volume: 35 ISSN: 1432-1238 ISO Abbreviation: Intensive Care Med Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 129-35 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. morisaki@z8.keio.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Respiratory
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physiopathology* Animals Bacterial Translocation / physiology* Endotoxemia / physiopathology, prevention & control* Hypercapnia / physiopathology* Intestinal Mucosa / enzymology, physiology* Male Peroxidase / analysis Rabbits Random Allocation Splanchnic Circulation / physiology |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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