Document Detail


Hypercapnia and resultant bicarbonate transfer processes in an elasmobranch fish (Scyliorhinus stellaris).
MedLine Citation:
PMID:  13888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to test the effects of hypercapnia on the acid-base status of fish, larger spotted dogfish were exposed to sudden changes of PCO2 in a closed seawater recirculation system. pH, PCO2 and PO2 were determined in arterial blood and seawater. The exchange of bicarbonate between extracellular space (ECS), intracellular space (ICS), and seawater (SW) was obtained from changes of the total bicarbonate amount in ECS and SW. After fourfold increase of PCO2 arterial pH fell markedly, but started to recover immediately towards control values. This was caused by compensatory accumulation of bicarbonate in the ECS. According to the origin of the extracellular bicarbonate increase three periods could be distinguished: 1.-- Bicarbonate transferred from ICS to both ECS and SW; 2. -- Bicarbonate transferred from both SW and ICS to ECS; 3. -- Bicarbonate transferred from SW to both ECS and ICS. After return to normocapnia similar periods occurred with opposite transfer directions and delayed period transitions. In the first period the ICS was found to be the only source for compensatory bicarbonate increases and even in the second period the ICS contributed to compensation of the extracellular pH. Thus bicarbonate exchange with the ICS appears to be an important regulatory mechanism diminishing the extracellular pH variations after changes in PCO2, before other compensatory mechanisms are initiated.
Authors:
N Heisler; H Weitz; A M Weitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  12     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1976 Jan-Feb
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  77-86     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bicarbonates / metabolism*
Blood
Carbon Dioxide / blood
Dogfish / metabolism*
Extracellular Space / metabolism
Hydrogen-Ion Concentration
Hypercapnia / blood,  metabolism*
Intracellular Fluid / metabolism
Seawater / analysis
Sharks / metabolism*
Chemical
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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