Document Detail

Hypercapnia in obstructive sleep apnoea syndrome.
MedLine Citation:
PMID:  10821977     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The reports on the prevalence of hypercapnia in Obstructive Sleep Apnoea Syndrome (OSAS) are conflicting. We studied the prevalence of hypercapnia in a population of OSAS patients referred to a Department of Respiratory Medicine and the mechanism of the respiratory failure in OSAS associated with Obesity Hypoventilation Syndrome (OHS) or with Chronic Obstructive Pulmonary Disease (COPD) (Overlap syndrome). METHODS: We studied 219 consecutive OSAS patients during a period of 3 years. We recorded age and anthropomorphic data and performed polysomnography and pulmonary function tests. In relation to the value of PaCO(2), the patients were divided in hypercapnic (PaCO(2)>45 mmHg) patients and normocapnic patients. They were also divided into three groups in relation to the presence of "simple" or "pure" OSAS, to the presence of OSAS associated with COPD, to the presence of OSAS associated with OHS. RESULTS: Seventeen per cent of the patients were hypercapnic. They were significantly heavier, had more severe lung function test abnormalities and more severe nocturnal oxyhemoglobin desaturations than the normocapnic ones, while Forced Expiratory Volume in one second as a percentage of Forced Vital Capacity (FEV1/FVC %) and Apnoea/Hypopnoea Index (AHI) were similar. OHS patients (13%) were significantly younger and heavier, had lower PaO(2) and higher PaCO(2) than "simple" OSAS patients (77%) and Overlap patients (10%) and had more severe restrictive defect. There was no difference in terms of AHI among the three groups, but nocturnal oxyhemoglobin desaturations were more severe in OHS group. In OHS group hypercapnia was correlated to FVC% of predicted and FEV1% of predicted and to the mean nocturnal oxyhemoglobin saturation; in Overlap patients PaCO(2) was correlated to Forced Expiratory Flow rate at low Vital Capacity. CONCLUSION: Seventeen per cent of OSAS patients referred to a Department of Respiratory Medicine were hypercapnic. Hypercapnia in OHS patients correlates to the restrictive ventilatory defect whereas in Overlap patients it seems to correlate to peripheral airways obstruction. The distinction between patients with "simple" or "pure" OSAS and patients affected by OSAS associated with OHS or COPD could be important not only for clinical and prognostic implications, but also for the consequences in terms of ventilatory treatment.
O Resta; M P Foschino Barbaro; P Bonfitto; S Talamo; V Mastrosimone; A Stefano; T Giliberti
Related Documents :
11548907 - Repeatability of sites of sleep-induced upper airway obstruction. a 2-night study based...
7897747 - Multiple chemical sensitivities--chemical sensitivity as a symptom of airway inflammation.
17026847 - Evidence of lower oxidative stress in the air spaces of patients with reversible copd.
22507947 - Auditory-perceptual voice characteristics in pre-operative patients undergoing thyroid ...
10792207 - A discordance of the cytochrome p450 2c19 genotype and phenotype in patients with advan...
10894597 - Resident participation in flexible sigmoidoscopy does not affect patient satisfaction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  56     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-01     Completed Date:  2000-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Centre of Sleep Disorders Breathing, Chair of Respiratory Disease, Department of Clinical Methodology and Medical Surgery Technology. University of Bari, Bari, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Distribution
Analysis of Variance
Hypercapnia / epidemiology*,  etiology
Middle Aged
Predictive Value of Tests
Regression Analysis
Respiratory Function Tests
Retrospective Studies
Risk Factors
Sex Distribution
Sleep Apnea, Obstructive / complications*,  diagnosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Incidence and onset of critical illness polyneuropathy in patients with septic shock.
Next Document:  A bone biopsy is mandatory in the optimal management of bone lesions in patients with a long-term hi...