Document Detail

Hypercapnia does not affect functional residual capacity enlargement induced by chronic hypoxia.
MedLine Citation:
PMID:  12470207     Owner:  NLM     Status:  MEDLINE    
To determine whether changes in partial pressure of CO2 participate in mechanism enlarging the lung functional residual capacity (FRC) during chronic hypoxia, we measured FRC and ventilation in rats exposed either to poikilocapnic (group H, F(I)O2 0.1, F(I)CO2 <0.01) or hypercapnic (group H+CO2, F(I)O2 0.1, F(I)CO2 0.04-0.05) hypoxia for the three weeks and in the controls (group C) breathing air. At the end of exposure a body plethysmograph was used to measure ventilatory parameters (V'(E), f(R), V(T)) and FRC during air breathing and acute hypoxia (10 % O2 in N2). The exposure to hypoxia for three weeks increased FRC measured during air breathing in both experimental groups (H: 3.0+/-0.1 ml, H+CO2: 3.1+/-0.2 ml, C: 1.8+/-0.2 ml). During the following acute hypoxia, we observed a significant increase of FRC in the controls (3.2+/-0.2 ml) and in both experimental groups (H: 3.5+/-0.2 ml, H+CO2: 3.6+/-0.2 ml). Because chronic hypoxia combined with chronic hypercapnia and chronic poikilocapnic hypoxia induced the same increase of FRC, we conclude that hypercapnia did not participate in the FRC enlargement during chronic hypoxia.
H Maxová; M Vízek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  51     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2002  
Date Detail:
Created Date:  2002-12-09     Completed Date:  2003-05-02     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  537-40     Citation Subset:  IM    
Institute of Pathological Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
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MeSH Terms
Anoxia / diagnosis*,  physiopathology*
Carbon Dioxide / blood
Chronic Disease
Functional Residual Capacity*
Hypercapnia / diagnosis*,  physiopathology*
Rats, Wistar
Respiratory Mechanics
Reg. No./Substance:
124-38-9/Carbon Dioxide

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